RhCl3-CATALYZED DISULFIDE EXCHANGE REACTION OF INSULIN AND DITHIODIGLYCOLIC ACID

被引：10

作者：

Arisawa, Mieko ^{[1
]}

Kuwajima, Manabu ^{[1
]}

Suwa, Atsushi ^{[1
]}

Yamaguchi, Masahiko ^{[2
]}

机构：

[1] Tohoku Univ, Dept Organ Chem, Grad Sch Pharmaceut Sci, Sendai, Miyagi 9808578, Japan

[2] Tohoku Univ, Adv Inst Mat Res, WPI Res Ctr, Sendai, Miyagi 9808577, Japan

来源：

HETEROCYCLES | 2010年 / 80卷 / 02期

关键词：

Rhodium Chloride; Disulfide Exchange Reaction; Catalysis; A7/B7; Disulfide; Insulin; OXIDATIVE CROSS-LINKING; RHODIUM CARBENOIDS; ALKYLATION; COMPLEXES;

D O I：

10.3987/COM-09-S(S)110

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

RhCl3 catalyzed the alkylthio exchange reaction of insulin and dithiodiglycolic acid in water under homogeneous conditions. Insulin was rapidly consumed, and mono- and bis-exchanged insulin were formed along with the disulfide exchanged A and B chain. The disulfide bond at the A7/B7 was initially exchanged, which was followed by the A6/A11 and A20/B19 disulfides.

引用

页码：1239 / 1248

页数：10

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