Reversal of natural killer cell exhaustion by TIM-3 blockade

被引：91
|
作者：
Gallois, Anne [1 ,2 ]
Silva, Ines [3 ]
Osman, Iman [3 ]
Bhardwaj, Nina [1 ,2 ]
机构：
[1] Tisch Canc Inst, New York, NY 10029 USA
[2] Icahn Sch Med Mt Sinai, New York, NY 10029 USA
[3] NYU, Langone Med Ctr, New York, NY USA
来源：
ONCOIMMUNOLOGY | 2014年 / 3卷 / 12期
关键词：
exhaustion; immune checkpoint; melanoma; natural killer cells; Tim-3; ANTITUMOR IMMUNITY; MELANOMA; CANCER;
D O I：
10.4161/21624011.2014.946365
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Natural killer (NK) cells are innate immune cells that become progressively exhausted in advanced stage cancer, crippling their ability to execute antitumor functions. We previously characterized the nature of NK cell exhaustion in metastatic melanoma patients, reporting a correlation with high expression of TIM-3. Blockade of this immune checkpoint molecule reversed the exhausted phenotype and improved NK cell function.
引用
收藏
页码：1 / 3
页数：3
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