In this work, Vanadis 6 cold work ledeburitic tool steel was cryogenically treated at different temperatures, and then low- or high-temperature tempered. The current research focused on the effect of process variables on the calculated wear rate, counterpart's material transfer, and friction coefficient. Results of pin-on-disk wear tests were evaluated using a Taguchi L18 orthogonal array with varying cryogenic temperatures (-75 degrees C, -140 degrees C, and -196 degrees C), tempering temperatures (170 degrees C and 530 degrees C), sliding velocity (0.064 m/s, 0.128 m/s, and 0.1885 m/s), and loads (1, 5, and 10 N) as parameters. Analysis of variance (ANOVA) was used to analyze the statistical significance and contributions of process factors to wear behavior. Confirmation tests were performed to verify the model accuracy, and the results show error values below 10%. The experimental works revealed that the wear rate increases with increasing load, but the friction coefficient is also strongly affected by the sliding speed. The dominant wear mechanism is adhesive with significant oxidation, abrasion, and delamination of adhered counterpart's material. To maximize the wear performance, it is necessary to process the steel at -140 degrees C with subsequent tempering at 170 degrees C. (c) 2022 The Author(s). Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).