Human immune globulin treatment controls Zika viremia in pregnant rhesus macaques

被引：7

作者：

Dudley, Dawn M. ^{[1
]}

Koenig, Michelle R. ^{[1
,2
]}

Stewart, Laurel M. ^{[1
]}

Semler, Matthew R. ^{[1
]}

Newman, Christina M. ^{[1
]}

Shepherd, Phoenix M. ^{[1
]}

Yamamoto, Keisuke ^{[1
]}

Breitbach, Meghan E. ^{[1
]}

Schotzko, Michele ^{[3
]}

Kohn, Sarah ^{[4
]}

Antony, Kathleen M. ^{[5
]}

Qiu, Hongyu ^{[6
]}

Tunga, Priyadarshini ^{[6
]}

Anderson, Deborah M. ^{[6
]}

Guo, Wendi ^{[7
]}

Dennis, Maria ^{[8
,9
]}

Singh, Tulika ^{[8
,9
]}

Rybarczyk, Sierra ^{[3
]}

Weiler, Andrea M. ^{[3
]}

Razo, Elaina ^{[10
]}

Mitzey, Ann ^{[2
]}

Zeng, Xiankun ^{[11
]}

Eickhoff, Jens C. ^{[12
]}

Mohr, Emma L. ^{[10
]}

Simmons, Heather A. ^{[3
]}

Fritsch, Michael K. ^{[1
]}

Mejia, Andres ^{[3
]}

Aliota, Matthew T. ^{[13
]}

Friedrich, Thomas C. ^{[3
,14
]}

Golos, Thaddeus G. ^{[2
,3
,5
]}

Kodihalli, Shantha ^{[6
]}

Permar, Sallie R. ^{[7
,15
]}

O'Connor, David H. ^{[1
,3
]}

机构：

[1] Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53706 USA

[2] Univ Wisconsin, Dept Comparat Biosci, 2015 Linden Dr W, Madison, WI 53706 USA

[3] Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53706 USA

[4] Univ Wisconsin, Dept Radiol, Madison, WI 53706 USA

[5] Univ Wisconsin, Dept Obstet & Gynecol, Madison, WI 53706 USA

[6] Canada Inc, Emergent BioSolut, Winnipeg, MB, Canada

[7] Duke Univ, Med Ctr, Dept Pharmacol & Canc Biol, Durham, NC USA

[8] Duke Univ, Med Ctr, Dept Pediat, Durham, NC 27710 USA

[9] Duke Univ, Med Ctr, Human Vaccine Inst, Durham, NC USA

[10] Univ Wisconsin, Dept Pediat, Madison, WI USA

[11] US Army, Med Res Inst Infect Dis, Frederick, MD USA

[12] Univ Wisconsin, Biostat & Med Informat, Madison, WI USA

[13] Univ Minnesota, Dept Vet & Biomed Sci, St Paul, MN USA

[14] Univ Wisconsin, Dept Pathobiol Sci, Madison, WI 53706 USA

[15] Weill Cornell Med, Dept Pediat, New York, NY USA

来源：

PLOS ONE | 2022年 / 17卷 / 07期

基金：

美国国家卫生研究院;

关键词：

ANTIBODY-DEPENDENT ENHANCEMENT; VIRUS-INFECTION; DISEASE;

D O I：

10.1371/journal.pone.0266664

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

There are currently no approved drugs to treat Zika virus (ZIKV) infection during pregnancy. Hyperimmune globulin products such as VARIZIG and WinRho are FDA-approved to treat conditions during pregnancy such as Varicella Zoster virus infection and Rh-incompatibility. We administered ZIKV-specific human immune globulin as a treatment in pregnant rhesus macaques one day after subcutaneous ZIKV infection. All animals controlled ZIKV viremia following the treatment and generated robust levels of anti-Zika virus antibodies in their blood. No adverse fetal or infant outcomes were identified in the treated animals, yet the placebo control treated animals also did not have signs related to congenital Zika syndrome (CZS). Human immune globulin may be a viable prophylaxis and treatment option for ZIKV infection during pregnancy, however, more studies are required to fully assess the impact of this treatment to prevent CZS.

引用

页数：23

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