Association Between the APOE ε2/ε4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans

被引：4
|
作者：
Ren, Dianxu [1 ,2 ]
Lopez, Oscar L. [3 ,4 ]
Lingler, Jennifer H. [1 ,4 ]
Conley, Yvette [1 ,5 ]
机构：
[1] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA 15261 USA
[5] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 81卷 / 03期
基金：
美国国家卫生研究院;
关键词：
African American; Alzheimer's disease; APOE; epsilon; 2/epsilon; 4; genotype; mild cognitive impairment; APOLIPOPROTEIN-E GENOTYPE; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; EPSILON-4; ALLELE; RISK-FACTOR; GENE; CLU;
D O I：
10.3233/JAD-201613
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the association between APOE epsilon 2/epsilon 4 with incident Alzheimer's disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer's Coordinating Center (NACC) from 2005 to September 2019. Compared to epsilon 3/epsilon 3 carriers, epsilon 2/epsilon 4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOE epsilon 2/epsilon 4 genotype is not associated with the incidence of AD and MCI among African Americans.
引用
收藏
页码：943 / 948
页数：6
相关论文
共 50 条
  • [41] Discriminating between Mild Cognitive Impairment and Alzheimer's Disease on the MoCA
    McDonald, Taylor
    Marker, Craig D.
    Ratcliffe, Lauren
    ARCHIVES OF CLINICAL NEUROPSYCHOLOGY, 2021, 36 (06) : 1046 - 1046
  • [42] APOE-Dependent Phenotypes in Subjects with Mild Cognitive Impairment Converting to Alzheimer's Disease
    Morgen, Katrin
    Froelich, Lutz
    Tost, Heike
    Plichta, Michael M.
    Koelsch, Heike
    Rakebrandt, Fabian
    Rienhoff, Otto
    Jessen, Frank
    Peters, Oliver
    Jahn, Holger
    Luckhaus, Christian
    Huell, Michael
    Gertz, Hermann-Josef
    Schroeder, Johannes
    Hampel, Harald
    Teipel, Stefan J.
    Pantel, Johannes
    Heuser, Isabella
    Wiltfang, Jens
    Ruether, Eckart
    Kornhuber, Johannes
    Maier, Wolfgang
    Meyer-Lindenberg, Andreas
    JOURNAL OF ALZHEIMERS DISEASE, 2013, 37 (02) : 389 - 401
  • [43] Incidence of Alzheimer disease by APOE genotype among elderly African Americans, Caucasians and Hispanics in New York City
    Tang, NX
    Stern, Y
    Schofield, P
    Tycko, B
    Mayeux, R
    NEUROLOGY, 1997, 48 (03) : 1091 - 1091
  • [44] Association of APOE Genotype With Heterogeneity of Cognitive Decline Rate in Alzheimer Disease
    Qian, Jing
    Betensky, Rebecca A.
    Hyman, Bradley T.
    Serrano-Pozo, Alberto
    NEUROLOGY, 2021, 96 (19) : E2414 - E2428
  • [45] The APOE-ε4 allele and the risk of Alzheimer disease among African Americans, Whites, and Hispanics
    Tang, MX
    Stern, Y
    Marder, K
    Bell, K
    Gurland, B
    Lantigua, R
    Andrews, H
    Feng, L
    Tycko, B
    Mayeux, R
    JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1998, 279 (10): : 751 - 755
  • [46] Sex and ApoE Genotype Differences in Treatment Response to Two Doses of Intranasal Insulin in Adults with Mild Cognitive Impairment or Alzheimer's Disease
    Claxton, Amy
    Baker, Laura D.
    Wilkinson, Charles W.
    Trittschuh, Emily H.
    Chapman, Darla
    Watson, G. Stennis
    Cholerton, Brenna
    Plymate, Stephen R.
    Arbuckle, Matthew
    Craft, Suzanne
    JOURNAL OF ALZHEIMERS DISEASE, 2013, 35 (04) : 789 - 797
  • [47] Inflammation in mild cognitive impairment and mild Alzheimer's disease
    Santana, I
    Guerreiro, R
    Paiva, A
    Sarmento, A
    Santiago, B
    Barbosa, V
    Oliveira, C
    NEUROBIOLOGY OF AGING, 2004, 25 : S534 - S534
  • [48] Association between DCHS2 gene and mild cognitive impairment and Alzheimer's disease in an elderly Brazilian sample
    Vieira, Renalice Neves
    Avila, Rafaela
    de Paula, Jonas Jardim
    Gualberto Cintra, Marco Tulio
    de Souza, Renan Pedra
    Nicolato, Rodrigo
    Malloy-Diniz, Leandro
    de Miranda, Debora Marques
    de Moraes, Edgar Nunes
    de Marco, Luiz Armando
    Romano-Silva, Marco Aurelio
    Camargos Bicalho, Maria Aparecida
    INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY, 2016, 31 (12) : 1337 - 1344
  • [49] Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease
    Liu, Hongliang
    Lutz, Michael
    Luo, Sheng
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 84 (03) : 1323 - 1335
  • [50] The Association of Essential Metals with APOE Genotype in Alzheimer's Disease
    Leko, Mirjana Babic
    Jurasovic, Jasna
    Perkovic, Matea Nikolac
    Spanic, Ena
    Sekovanic, Ankica
    Orct, Tatjana
    Skudar, Vesna Lukinovic
    Baronica, Koraljka Bacic
    Kidemet-Piskac, Spomenka
    Vogrinc, Zeljka
    Pivac, Nela
    Borovecki, Fran
    Hof, Patrick R.
    Simic, Goran
    JOURNAL OF ALZHEIMERS DISEASE, 2021, 82 (02) : 661 - 672
12345