Association Between the APOE ε2/ε4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans

被引：4

作者：

Ren, Dianxu ^{[1
,2
]}

Lopez, Oscar L. ^{[3
,4
]}

Lingler, Jennifer H. ^{[1
,4
]}

Conley, Yvette ^{[1
,5
]}

机构：

[1] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 81卷 / 03期

基金：

美国国家卫生研究院;

关键词：

African American; Alzheimer's disease; APOE; epsilon; 2/epsilon; 4; genotype; mild cognitive impairment; APOLIPOPROTEIN-E GENOTYPE; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; EPSILON-4; ALLELE; RISK-FACTOR; GENE; CLU;

D O I：

10.3233/JAD-201613

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the association between APOE epsilon 2/epsilon 4 with incident Alzheimer's disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer's Coordinating Center (NACC) from 2005 to September 2019. Compared to epsilon 3/epsilon 3 carriers, epsilon 2/epsilon 4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOE epsilon 2/epsilon 4 genotype is not associated with the incidence of AD and MCI among African Americans.

引用

页码：943 / 948

页数：6

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