Association Between the APOE ε2/ε4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans

被引：4
|
作者：
Ren, Dianxu [1 ,2 ]
Lopez, Oscar L. [3 ,4 ]
Lingler, Jennifer H. [1 ,4 ]
Conley, Yvette [1 ,5 ]
机构：
[1] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA
[2] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA
[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA
[4] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA 15261 USA
[5] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 81卷 / 03期
基金：
美国国家卫生研究院;
关键词：
African American; Alzheimer's disease; APOE; epsilon; 2/epsilon; 4; genotype; mild cognitive impairment; APOLIPOPROTEIN-E GENOTYPE; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; EPSILON-4; ALLELE; RISK-FACTOR; GENE; CLU;
D O I：
10.3233/JAD-201613
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
We examined the association between APOE epsilon 2/epsilon 4 with incident Alzheimer's disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer's Coordinating Center (NACC) from 2005 to September 2019. Compared to epsilon 3/epsilon 3 carriers, epsilon 2/epsilon 4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOE epsilon 2/epsilon 4 genotype is not associated with the incidence of AD and MCI among African Americans.
引用
收藏
页码：943 / 948
页数：6
相关论文
共 50 条
  • [1] Association between ApoE genotype and Alzheimer's disease in African Americans
    Graff-Radford, N
    Hutton, M
    Adamson, J
    Willis, F
    Green, R
    Cupples, A
    Farrer, L
    Go, R
    Edeki, T
    Griffith, P
    Williams, M
    Hipps, Y
    Bachman, D
    Haines, J
    NEUROBIOLOGY OF AGING, 2002, 23 (01) : S304 - S304
  • [2] Cognitive impairment in Alzheimer's disease is modified by APOE genotype
    van der Vlies, Annelies E.
    Pijnenburg, Yolande A. L.
    Koene, Teddy
    Klein, Martin
    Kok, Astrid
    Scheltens, Philip
    van der Flier, Wiesje M.
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2007, 24 (02) : 98 - 103
  • [3] Interaction between APOE ε4 genotype and education on mild cognitive impairment
    Frank, M.
    Hensel, J.
    Baak, L.
    Dragano, N.
    Weimar, C.
    Jokisch, M.
    Schmidt, B.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2022, 32 : III345 - III345
  • [4] Association of CSF GAP-43 and APOE ε4 with Cognition in Mild Cognitive Impairment and Alzheimer's Disease
    Zhu, Yueli
    Guo, Xiaoming
    Zhu, Feng
    Zhang, Qin
    Yang, Yunmei
    CELLS, 2023, 12 (01)
  • [5] Relationship between APOE and Alzheimer's disease in African Americans
    Harwood, DG
    Barker, WW
    Dunkley, M
    Mullan, M
    St George-Hyslop, PH
    Duara, R
    NEUROLOGY, 2001, 56 (08) : A112 - A112
  • [6] APOE Genotype in the Diagnosis of Alzheimer's Disease in Patients With Cognitive Impairment
    Sun, Xiaoyan
    Nicholas, Joyce
    Walker, Aljoeson
    Wagner, Mark T.
    Bachman, David
    AMERICAN JOURNAL OF ALZHEIMERS DISEASE AND OTHER DEMENTIAS, 2012, 27 (05): : 315 - 320
  • [7] Frequency and severity of neuropsychiatric symptoms in Alzheimer's disease and mild cognitive impairment: Influence of the APOE genotype
    Alvarez, XA
    Laredo, M
    Couceiro, V
    Sampedro, C
    Cacabelos, R
    Illescas, E
    Vargas, M
    Moessler, H
    INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2004, 7 : S384 - S384
  • [8] The Effect of the APOE Genotype on Individual BrainAGE in Normal Aging, Mild Cognitive Impairment, and Alzheimer's Disease
    Loewe, Luise Christine
    Gaser, Christian
    Franke, Katja
    PLOS ONE, 2016, 11 (07):
  • [9] The association between APOE genotype and memory dysfunction in subjects with mild cognitive impairment is related to age and Alzheimer pathology
    Ramakers, I. H. G. B.
    Visser, P. J.
    Aalten, P.
    Bekers, O.
    Sleegers, K.
    Van Broeckhoven, C. L.
    Jolles, J.
    Verhey, F. R. J.
    DEMENTIA AND GERIATRIC COGNITIVE DISORDERS, 2008, 26 (02) : 101 - 108
  • [10] The Effect of the APOE ε2ε4 Genotype on the Development of Alzheimer's Disease (AD) and Mild Cognitive Impairment (MCI) in Non-Latino Whites
    Ren, Dianxu
    Lopez, Oscar L.
    Lingler, Jennifer H.
    Conley, Yvette
    JOURNAL OF THE AMERICAN GERIATRICS SOCIETY, 2020, 68 (05) : 1044 - 1049
12345