Association Between the APOE ε2/ε4 Genotype and Alzheimer's Disease and Mild Cognitive Impairment Among African Americans

被引：4

作者：

Ren, Dianxu ^{[1
,2
]}

Lopez, Oscar L. ^{[3
,4
]}

Lingler, Jennifer H. ^{[1
,4
]}

Conley, Yvette ^{[1
,5
]}

机构：

[1] Univ Pittsburgh, Sch Nursing, Pittsburgh, PA 15261 USA

[2] Univ Pittsburgh, Dept Biostat, Pittsburgh, PA 15261 USA

[3] Univ Pittsburgh, Sch Med, Dept Neurol, Pittsburgh, PA 15261 USA

[4] Univ Pittsburgh, Alzheimers Dis Res Ctr, Pittsburgh, PA 15261 USA

[5] Univ Pittsburgh, Dept Human Genet, Pittsburgh, PA 15261 USA

来源：

JOURNAL OF ALZHEIMERS DISEASE | 2021年 / 81卷 / 03期

基金：

美国国家卫生研究院;

关键词：

African American; Alzheimer's disease; APOE; epsilon; 2/epsilon; 4; genotype; mild cognitive impairment; APOLIPOPROTEIN-E GENOTYPE; GENOME-WIDE ASSOCIATION; IDENTIFIES VARIANTS; EPSILON-4; ALLELE; RISK-FACTOR; GENE; CLU;

D O I：

10.3233/JAD-201613

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

We examined the association between APOE epsilon 2/epsilon 4 with incident Alzheimer's disease (AD) and mild cognitive impairment (MCI) among African Americans using the national dataset from the National Alzheimer's Coordinating Center (NACC) from 2005 to September 2019. Compared to epsilon 3/epsilon 3 carriers, epsilon 2/epsilon 4 carriers exhibited a similar risk of incident AD (adjusted hazard ratio [aHR] = 0.85, 95% CI [0.39, 1.84]) among the AD cohort and similar risk of incident MCI (aHR = 0.88, 95% CI [0.51, 1.50]) among the MCI cohort. Our findings suggest that, unlike the increased risk of AD and MCI in non-Latino whites, APOE epsilon 2/epsilon 4 genotype is not associated with the incidence of AD and MCI among African Americans.

引用

页码：943 / 948

页数：6

共 17 条

[1] The National Alzheimer's Coordinating Center (NACC) database: The uniform data set [J].

Beekly, Duane L. ;

Ramos, Erin M. ;

Lee, William W. ;

Deitrich, Woodrow D. ;

Jacka, Mary E. ;

Wu, Joylee ;

Hubbard, Janene L. ;

Koepsell, Thomas D. ;

Morris, John C. ;

Kukull, Walter A. .

ALZHEIMER DISEASE & ASSOCIATED DISORDERS, 2007, 21 (03) :249-258

[2] APOLIPOPROTEIN-E, EPSILON-4 ALLELE AS A MAJOR RISK FACTOR FOR SPORADIC EARLY AND LATE-ONSET FORMS OF ALZHEIMERS-DISEASE - ANALYSIS OF THE 19Q13.2 CHROMOSOMAL REGION [J].

CHARTIERHARLIN, MC ;

PARFITT, M ;

LEGRAIN, S ;

PEREZTUR, J ;

BROUSSEAU, T ;

EVANS, A ;

BERR, C ;

VIDAL, O ;

ROQUES, P ;

GOURLET, V ;

FRUCHART, JC ;

DELACOURTE, A ;

ROSSOR, M ;

AMOUYEL, P .

HUMAN MOLECULAR GENETICS, 1994, 3 (04) :569-574

[3] GENE DOSE OF APOLIPOPROTEIN-E TYPE-4 ALLELE AND THE RISK OF ALZHEIMERS-DISEASE IN LATE-ONSET FAMILIES [J].

CORDER, EH ;

SAUNDERS, AM ;

STRITTMATTER, WJ ;

SCHMECHEL, DE ;

GASKELL, PC ;

SMALL, GW ;

ROSES, AD ;

HAINES, JL ;

PERICAKVANCE, MA .

SCIENCE, 1993, 261 (5123) :921-923

[4] Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis [J].

Farrer, LA ;

Cupples, LA ;

Haines, JL ;

Hyman, B ;

Kukull, WA ;

Mayeux, R ;

Myers, RH ;

PericakVance, MA ;

Risch, N ;

vanDuijn, CM .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16) :1349-1356

[5] APOE and Alzheimer disease: a major gene with semi-dominant inheritance [J].

Genin, E. ;

Hannequin, D. ;

Wallon, D. ;

Sleegers, K. ;

Hiltunen, M. ;

Combarros, O. ;

Bullido, M. J. ;

Engelborghs, S. ;

De Deyn, P. ;

Berr, C. ;

Pasquier, F. ;

Dubois, B. ;

Tognoni, G. ;

Fievet, N. ;

Brouwers, N. ;

Bettens, K. ;

Arosio, B. ;

Coto, E. ;

Del Zompo, M. ;

Mateo, I. ;

Epelbaum, J. ;

Frank-Garcia, A. ;

Helisalmi, S. ;

Porcellini, E. ;

Pilotto, A. ;

Forti, P. ;

Ferri, R. ;

Scarpini, E. ;

Siciliano, G. ;

Solfrizzi, V. ;

Sorbi, S. ;

Spalletta, G. ;

Valdivieso, F. ;

Vepsalainen, S. ;

Alvarez, V. ;

Bosco, P. ;

Mancuso, M. ;

Panza, F. ;

Nacmias, B. ;

Bossu, P. ;

Hanon, O. ;

Piccardi, P. ;

Annoni, G. ;

Seripa, D. ;

Galimberti, D. ;

Licastro, F. ;

Soininen, H. ;

Dartigues, J-F ;

Kamboh, M. I. ;

Van Broeckhoven, C. .

MOLECULAR PSYCHIATRY, 2011, 16 (09) :903-907

[6] Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease [J].

Harold, Denise ;

Abraham, Richard ;

Hollingworth, Paul ;

Sims, Rebecca ;

Gerrish, Amy ;

Hamshere, Marian L. ;

Pahwa, Jaspreet Singh ;

Moskvina, Valentina ;

Dowzell, Kimberley ;

Williams, Amy ;

Jones, Nicola ;

Thomas, Charlene ;

Stretton, Alexandra ;

Morgan, Angharad R. ;

Lovestone, Simon ;

Powell, John ;

Proitsi, Petroula ;

Lupton, Michelle K. ;

Brayne, Carol ;

Rubinsztein, David C. ;

Gill, Michael ;

Lawlor, Brian ;

Lynch, Aoibhinn ;

Morgan, Kevin ;

Brown, Kristelle S. ;

Passmore, Peter A. ;

Craig, David ;

McGuinness, Bernadette ;

Todd, Stephen ;

Holmes, Clive ;

Mann, David ;

Smith, A. David ;

Love, Seth ;

Kehoe, Patrick G. ;

Hardy, John ;

Mead, Simon ;

Fox, Nick ;

Rossor, Martin ;

Collinge, John ;

Maier, Wolfgang ;

Jessen, Frank ;

Schuermann, Britta ;

van den Bussche, Hendrik ;

Heuser, Isabella ;

Kornhuber, Johannes ;

Wiltfang, Jens ;

Dichgans, Martin ;

Froelich, Lutz ;

Hampel, Harald ;

Huell, Michael .

NATURE GENETICS, 2009, 41 (10) :1088-U61

[7] APOE ε4 and the risk for Alzheimer disease and cognitive decline in African Americans and Yoruba [J].

Hendrie, Hugh C. ;

Murrell, Jill ;

Baiyewu, Olusegun ;

Lane, Kathleen A. ;

Purnell, Christianna ;

Ogunniyi, Adesola ;

Unverzagt, Frederick W. ;

Hall, Kathleen ;

Callahan, Christopher M. ;

Saykin, Andrew J. ;

Gureje, Oye ;

Hake, Ann ;

Foroud, Tatiana ;

Gao, Sujuan .

INTERNATIONAL PSYCHOGERIATRICS, 2014, 26 (06) :977-985

[8]

Houlden H, 1998, AM J MED GENET, V81, P117, DOI 10.1002/(SICI)1096-8628(19980207)81:1<117::AID-AJMG19>3.0.CO

[9]

2-M

[10] Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease [J].

Lambert, Jean-Charles ;

Heath, Simon ;

Even, Gael ;

Campion, Dominique ;

Sleegers, Kristel ;

Hiltunen, Mikko ;

Combarros, Onofre ;

Zelenika, Diana ;

Bullido, Maria J. ;

Tavernier, Beatrice ;

Letenneur, Luc ;

Bettens, Karolien ;

Berr, Claudine ;

Pasquier, Florence ;

Fievet, Nathalie ;

Barberger-Gateau, Pascale ;

Engelborghs, Sebastiaan ;

De Deyn, Peter ;

Mateo, Ignacio ;

Franck, Ana ;

Helisalmi, Seppo ;

Porcellini, Elisa ;

Hanon, Olivier ;

de Pancorbo, Marian M. ;

Lendon, Corinne ;

Dufouil, Carole ;

Jaillard, Celine ;

Leveillard, Thierry ;

Alvarez, Victoria ;

Bosco, Paolo ;

Mancuso, Michelangelo ;

Panza, Francesco ;

Nacmias, Benedetta ;

Bossu, Paola ;

Piccardi, Paola ;

Annoni, Giorgio ;

Seripa, Davide ;

Galimberti, Daniela ;

Hannequin, Didier ;

Licastro, Federico ;

Soininen, Hilkka ;

Ritchie, Karen ;

Blanche, Helene ;

Dartigues, Jean-Francois ;

Tzourio, Christophe ;

Gut, Ivo ;

Van Broeckhoven, Christine ;

Alperovitch, Annick ;

Lathrop, Mark ;

Amouyel, Philippe .

NATURE GENETICS, 2009, 41 (10) :1094-U68

← 1 2 →