Formin-binding proteins: Modulators of formin-dependent actin polymerization

被引:49
作者
Aspenstrom, Pontus [1 ]
机构
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SE-17177 Stockholm, Sweden
来源
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 2010年 / 1803卷 / 02期
基金
瑞典研究理事会;
关键词
Formin; DRF; Profilin; Actin; FH2; PCH; F-BAR; Src; IQGAP; DIAPHANOUS-RELATED FORMIN; MDIA-INTERACTING PROTEIN; REGULATES CELL MOTILITY; STRESS FIBER FORMATION; SRC TYROSINE KINASE; WASP-WIP COMPLEX; SACCHAROMYCES-CEREVISIAE; ARP2/3; COMPLEX; FISSION YEAST; SMALL GTPASE;
D O I
10.1016/j.bbamcr.2009.06.002
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain and, although the nucleation per se does not require additional factors, formin-binding proteins have been shown to be essential for the regulation of formin-dependent actin assembly in vivo. This regulation could be accomplished by formin-binding proteins being directly involved in formin-driven actin nucleation, by formin-binding proteins influencing the activated state of the formins, by linking formin-driven actin polymerization to Arp2/3 driven actin polymerization, or by influencing the subcellular localization of the formins. This review article will focus on mammalian formin-binding proteins and their roles during vital cellular processes, such as cell migration, cell division and intracellular trafficking. (C) 2009 Elsevier B.V. All rights reserved.
引用
收藏
页码:174 / 182
页数:9
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