共 108 条
Formin-binding proteins: Modulators of formin-dependent actin polymerization
被引:49
作者:
Aspenstrom, Pontus
[1
]
机构:
[1] Karolinska Inst, Dept Microbiol Tumor & Cell Biol MTC, SE-17177 Stockholm, Sweden
来源:
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
|
2010年
/
1803卷
/
02期
基金:
瑞典研究理事会;
关键词:
Formin;
DRF;
Profilin;
Actin;
FH2;
PCH;
F-BAR;
Src;
IQGAP;
DIAPHANOUS-RELATED FORMIN;
MDIA-INTERACTING PROTEIN;
REGULATES CELL MOTILITY;
STRESS FIBER FORMATION;
SRC TYROSINE KINASE;
WASP-WIP COMPLEX;
SACCHAROMYCES-CEREVISIAE;
ARP2/3;
COMPLEX;
FISSION YEAST;
SMALL GTPASE;
D O I:
10.1016/j.bbamcr.2009.06.002
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
Formins represent a major branch of actin nucleators along with the Arp2/3 complex, Spire and Cordon-bleu. Formin-mediated actin nucleation requires the formin homology 2 domain and, although the nucleation per se does not require additional factors, formin-binding proteins have been shown to be essential for the regulation of formin-dependent actin assembly in vivo. This regulation could be accomplished by formin-binding proteins being directly involved in formin-driven actin nucleation, by formin-binding proteins influencing the activated state of the formins, by linking formin-driven actin polymerization to Arp2/3 driven actin polymerization, or by influencing the subcellular localization of the formins. This review article will focus on mammalian formin-binding proteins and their roles during vital cellular processes, such as cell migration, cell division and intracellular trafficking. (C) 2009 Elsevier B.V. All rights reserved.
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页码:174 / 182
页数:9
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