A developmental view of microRNA function

被引：536

作者：

Zhao, Yong

Srivastava, Deepak

机构：

[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA

[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA

[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 04期

关键词：

D O I：

10.1016/j.tibs.2007.02.006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.

引用

收藏

页码：189 / 197

页数：9

相关论文

共 87 条

[61] Conservation of the sequence and temporal expression of let-7 heterochronic regulatory RNA [J].

Pasquinelli, AE ;

Reinhart, BJ ;

Slack, F ;

Martindale, MQ ;

Kuroda, MI ;

Maller, B ;

Hayward, DC ;

Ball, EE ;

Degnan, B ;

Müller, P ;

Spring, J ;

Srinivasan, A ;

Fishman, M ;

Finnerty, J ;

Corbo, J ;

Levine, M ;

Leahy, P ;

Davidson, E ;

Ruvkun, G .

NATURE, 2000, 408 (6808) :86-89

[62] A pancreatic islet-specific microRNA regulates insulin secretion [J].

Poy, MN ;

Eliasson, L ;

Krutzfeldt, J ;

Kuwajima, S ;

Ma, XS ;

MacDonald, PE ;

Pfeffer, S ;

Tuschl, T ;

Rajewsky, N ;

Rorsman, P ;

Stoffel, M .

NATURE, 2004, 432 (7014) :226-230

[63] microRNA target predictions in animals [J].

Rajewsky, Nikolaus .

NATURE GENETICS, 2006, 38 (Suppl 6) :S8-S13

[64] Myogenic factors that regulate expression of muscle-specific, microRNAs [J].

Rao, Prakash K. ;

Kumar, Roshan M. ;

Farkhondeh, Mina ;

Baskerville, Scott ;

Lodish, Harvey F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2006, 103 (23) :8721-8726

[65] SMEDWI-2 is a PIWI-like protein that regulates planarian stem cells [J].

Reddien, PW ;

Oviedo, NJ ;

Jennings, JR ;

Jenkin, JC ;

Alvarado, AS .

SCIENCE, 2005, 310 (5752) :1327-1330

[66] The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J].

Reinhart, BJ ;

Slack, FJ ;

Basson, M ;

Pasquinelli, AE ;

Bettinger, JC ;

Rougvie, AE ;

Horvitz, HR ;

Ruvkun, G .

NATURE, 2000, 403 (6772) :901-906

[67] Identification of mammalian microRNA host genes and transcription units [J].

Rodriguez, A ;

Griffiths-Jones, S ;

Ashurst, JL ;

Bradley, A .

GENOME RESEARCH, 2004, 14 (10A) :1902-1910

[68] MyoD inhibits Fstl1 and Utrn expression by inducing transcription of miR-206 [J].

Rosenberg, Miriam I. ;

Georges, Sara A. ;

Asawachaicharn, Amy ;

Analau, Erwin ;

Tapscott, Stephen J. .

JOURNAL OF CELL BIOLOGY, 2006, 175 (01) :77-85

[69] A brain-specific microRNA regulates dendritic spine development [J].

Schratt, GM ;

Tuebing, F ;

Nigh, EA ;

Kane, CG ;

Sabatini, ME ;

Kiebler, M ;

Greenberg, ME .

NATURE, 2006, 439 (7074) :283-289

[70] Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation [J].

Sempere, LF ;

Freemantle, S ;

Pitha-Rowe, I ;

Moss, E ;

Dmitrovsky, E ;

Ambros, V .

GENOME BIOLOGY, 2004, 5 (03)

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