A developmental view of microRNA function

被引：536
作者：
Zhao, Yong
Srivastava, Deepak
机构：
[1] Univ Calif San Francisco, Gladstone Inst Cardiovasc Dis, San Francisco, CA 94158 USA
[2] Univ Calif San Francisco, Dept Pediat, San Francisco, CA 94158 USA
[3] Univ Calif San Francisco, Dept Biochem & Biophys, San Francisco, CA 94158 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2007年 / 32卷 / 04期
关键词：
D O I：
10.1016/j.tibs.2007.02.006
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
MicroRNAs (miRNAs) are genomically encoded small non-coding RNAs that regulate flow of genetic information by controlling translation or stability of mRNAs. Recent recognition that many miRNAs are expressed in a tissue-specific manner during development of organisms, from worms to humans, has revealed a novel mechanism by which the proteome is regulated during the dynamic events of cell-lineage decisions and morphogenesis. Advances in the understanding of miRNA biogenesis, target recognition and participation in regulatory networks demonstrate a role for miRNAs in lineage decisions of progenitor cells and organogenesis. Future discoveries in this area are likely to reveal developmental-regulation and disease mechanisms related to miRNAs.
引用
收藏
页码：189 / 197
页数：9
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