Neuromyelitis Optica Spectrum Disorders

被引：40

作者：

Akaishi, Tetsuya ^{[1
]}

Nakashima, Ichiro ^{[1
]}

Sato, Douglas Kazutoshi ^{[1
,2
,3
]}

Takahashi, Toshiyuki ^{[1
,4
]}

Fujihara, Kazuo ^{[1
,2
,5
]}

机构：

[1] Tohoku Univ, Dept Neurol, Grad Sch Med, Aoba Ku, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan

[2] Tohoku Univ, Grad Sch Med, Dept Multiple Sclerosis Therapeut, Aoba Ku, 1-1 Seiryomachi, Sendai, Miyagi 9808574, Japan

[3] Pontificia Univ Catolica Rio Grande do Sul, Brain Inst, Ave Ipiranga,6690 Bldg 63, BR-90610000 Porto Alegre, RS, Brazil

[4] Yonezawa Natl Hosp, Dept Neurol, 26100-1 Misawa, Yonezawa, Yamagata 9921202, Japan

[5] Fukushima Med Univ, Dept Multiple Sclerosis Therapeut, Southern TOHOKU Res Inst Neurosci, Multiple Sclerosis & Neuromyelitis Opt Ctr,Sch Me, 7-115 Yatsuyamada, Koriyama, Fukushima 9638563, Japan

来源：

NEUROIMAGING CLINICS OF NORTH AMERICA | 2017年 / 27卷 / 02期

基金：

日本学术振兴会;

关键词：

Neuromyelitis optica spectrum disorders; Anti-aquaporin-4; antibody; Anti-myelin oligodendrocyte glycoprotein antibody; MR imaging; Optical coherence tomography; MYELIN-OLIGODENDROCYTE GLYCOPROTEIN; DIAGNOSTIC-CRITERIA; INTRACTABLE HICCUP; ANTIBODY; MRI; DEMYELINATION; NEURITIS; LESIONS; NAUSEA;

D O I：

10.1016/j.nic.2016.12.010

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuromyelitis optica (NMO) is clinically characterized by severe optic neuritis and transverse myelitis, but recent studies with anti-aquaporin-4-antibody specific to NMO have revealed that the clinical spectrum is wider than previously thought. International consensus diagnostic criteria propose NMO spectrum disorders (NMOSD) as the term to define the entire spectrum including typical NMO, optic neuritis, acute myelitis, brain syndrome, and their combinations. NMOSD is now divided into anti-aquaporin-4-antibody-seropositive NMOSD and-seronegative NMOSD (or unknown serostatus). MR imaging and optical coherence tomography are indispensable in the diagnosis and evaluation of NMOSD. This article reviews the clinical and MR imaging findings of anti-aquaporin-4-antibody-seropositive and anti-myelin oligodendrocyte glycoprotein-antibody-seropositive NMOSD.

引用

页码：251 / +

页数：17

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