Enhanced Resolution of Low Molecular Weight Poly(Ethylene Glycol) in Nanopore Analysis
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作者:
Cao, Chan
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机构:E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Cao, Chan
Ying, Yi-Lun
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机构:E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Ying, Yi-Lun
Gu, Zhen
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机构:E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Gu, Zhen
Long, Yi-Tao
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E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R ChinaE China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
Long, Yi-Tao
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机构:
[1] E China Univ Sci & Technol, Key Lab Adv Mat, Shanghai 200237, Peoples R China
A design with conjugation of DNA hairpin structure to the poly(ethylene glycol) molecule was presented to enhance the temporal resolution of low molecular weight poly(ethylene glycol) in nanopore studies. By the virtue of this design, detection of an individual PEG with molecular weight as low as 140 Da was achieved at the single-molecule level in solution, which provides a novel strategy for characterization of an individual small molecule within a nanopore. Furthermore, we found that the current duration time of poly(ethylene glycol) was scaled with the relative molecular weight, which has a potential application in single-molecule detection.