Synthesis and Biological Activity of Estafiatin Phosphonate Derivatives

被引：6

作者：

Suleimen, E. M. ^{[1
]}

Dzhalmakhanbetova, R. I. ^{[1
]}

Pak, R. N. ^{[2
]}

Kulyyasov, A. T. ^{[2
]}

Adekenov, S. M. ^{[2
]}

机构：

[1] Eurasian Natl Univ, LN Gumilev Inst Appl Chem, Astana 010008, Kazakhstan

[2] Phytochem Corp, Karaganda 100019, Kazakhstan

来源：

CHEMISTRY OF NATURAL COMPOUNDS | 2014年 / 50卷 / 05期

关键词：

sesquiterpene lactones; chemical modification; phosphorus-derivatives; two-dimensional spectra; antimicrobial activity;

D O I：

10.1007/s10600-014-1097-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new dialkylphosphonate derivatives 2-5 were prepared for the first time from the guaiane-type sesquiterpene lactone estafiatin (1), which was isolated from the aerial part of Achillea nobilis. Their structures were elucidated using PMR, C-13 NMR, two-dimensional H-1-H-1 COSY, C-13-H-1 COLOC, and P-31-H-1 spectroscopy. The estafiatin phosphorylation reaction was highly chemo- and stereoselective. The antimicrobial activity of the prepared derivatives was studied.

引用

页码：846 / 849

页数：4

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