Cerenkov luminescence tomography for small-animal imaging

被引：138

作者：

Li, Changqing ^{[1
]}

Mitchell, Gregory S. ^{[1
]}

Cherry, Simon R. ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Biomed Engn, Davis, CA 95616 USA

来源：

OPTICS LETTERS | 2010年 / 35卷 / 07期

基金：

美国国家卫生研究院;

关键词：

OPTICAL TOMOGRAPHY;

D O I：

10.1364/OL.35.001109

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

Cerenkov radiation is a well-known phenomenon in which optical photons are emitted by charged particles moving faster than the speed of light in a medium. We have observed Cerenkov photons emitted from beta-emitting radiotracers such as (18)F-fluorodeoxyglucose using a sensitive CCD camera. Phantom and in vivo mouse imaging experiments have demonstrated that surface measurements of the emitted Cerenkov optical photons could be used to reconstruct the radiotracer activity distribution inside an object by modeling the optical photon propagation with the diffusion equation and reconstructing the optical emission source distribution iteratively with a preconditioned conjugate gradient method. (C) 2010 Optical Society of America

引用

页码：1109 / 1111

页数：3

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