A curious case of oxaliplatin-induced neurotoxicity: Recurrent, self-limiting dysarthria

被引：9

作者：

Joseph, Ranjit

Dasanu, Constantin A.

机构：

[1] Department of Medicine, University of Connecticut Health Center, 263 Farmington Avenue, Farmington, 06030-1235, CT

[2] Department of Hematology-Oncology, St Francis Hospital, Medical Center, Hartford, CT

来源：

JOURNAL OF ONCOLOGY PHARMACY PRACTICE | 2014年 / 20卷 / 05期

关键词：

Oxaliplatin; FOLFIRINOX; neurotoxicity; dysarthria;

D O I：

10.1177/1078155213506477

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

This report presents a unique case of oxaliplatin-induced neurotoxicity featuring acute, recurrent, self-limiting dysarthria following multiple subsequent infusions of oxaliplatin. A 65-year-old man started chemotherapy for metastatic pancreatic adenocarcinoma with oxaliplatin irinotecan leucovorin-5-fluorouracil (FOLFIRINOX). During the first and subsequent infusions of oxaliplatin, the patient developed episodes of dysarthria that lasted between 2 and 4 h after oxaliplatin infusions, followed by their complete and uneventful resolution. A thorough neurological examination showed no new neurologic deficits except for very fine tongue fasciculations. Recognizing this self-limiting toxic effect of oxaliplatin is important in order to avoid dose reductions that may affect clinical outcomes.

引用

页码：393 / 396

页数：4

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