New Designs for Phototherapeutic Transition Metal Complexes

被引：343

作者：

Imberti, Cinzia ^{[3
]}

Zhang, Pingyu ^{[1
,3
]}

Huang, Huaiyi ^{[2
,3
]}

Sadler, Peter J. ^{[3
]}

机构：

[1] Shenzhen Univ, Coll Chem & Environm Engn, Shenzhen 518060, Peoples R China

[2] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510275, Guangdong, Peoples R China

[3] Univ Warwick, Dept Chem, Coventry CV4 7AL, W Midlands, England

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2020年 / 59卷 / 01期

基金：

英国医学研究理事会; 美国国家科学基金会; 英国惠康基金; 英国工程与自然科学研究理事会;

关键词：

anticancer; metal complexes; photoactivated chemotherapy; photodynamic therapy; EFFICIENT PHOTODYNAMIC THERAPY; PLATINUM(IV) DIAZIDO COMPLEXES; NITRIC-OXIDE RELEASE; VISIBLE-LIGHT; CELLULAR ACCUMULATION; CROSS-LINKING; CANCER-CELLS; PHOTOSENSITIZERS; RUTHENIUM(II); AGENTS;

D O I：

10.1002/anie.201905171

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In this Minireview, we highlight recent advances in the design of transition metal complexes for photodynamic therapy (PDT) and photoactivated chemotherapy (PACT), and discuss the challenges and opportunities for the translation of such agents into clinical use. New designs for light-activated transition metal complexes offer photoactivatable prodrugs with novel targeted mechanisms of action. Light irradiation can provide spatial and temporal control of drug activation, increasing selectivity and reducing side-effects. The photophysical and photochemical properties of transition metal complexes can be controlled by the appropriate choice of the metal, its oxidation state, the number and types of ligands, and the coordination geometry.

引用

页码：61 / 73

页数：13

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