Calbindin-1 association and Parkinson's disease

被引：11

作者：

Soto-Ortolaza, A. I.

Behrouz, B.

Wider, C. ^{[1
]}

Vilarino-Guell, C.

Heckman, M. G. ^{[2
]}

Aasly, J. O. ^{[3
,4
]}

Gibson, J. Mark ^{[5
]}

Lynch, T. ^{[6
,7
]}

Jasinska-Myga, B. ^{[8
]}

Krygowska-Wajs, A. ^{[9
]}

Opala, G. ^{[8
]}

Barcikowska, M. ^{[10
]}

Czyzewski, K. ^{[11
]}

Uitti, R. J. ^{[12
]}

Wszolek, Z. K. ^{[12
]}

Farrer, M. J.

Ross, O. A.

机构：

[1] Mayo Clin, Dept Neurosci, Mol Genet Lab & Core,Coll Med, Morris K Udall Parkinsons Dis Res Ctr Excellence, Jacksonville, FL 32224 USA

[2] Mayo Clin, Biostat Unit, Coll Med, Jacksonville, FL 32224 USA

[3] St Olavs Hosp, Dept Neurol, Trondheim, Norway

[4] Norwegian Univ Sci & Technol, Dept Neurosci, N-7034 Trondheim, Norway

[5] Royal Victoria Hosp, Dept Neurol, Belfast BT12 6BA, Antrim, North Ireland

[6] Mater Misericordiae Univ Hosp, Dept Neurol, Dublin 7, Ireland

[7] Univ Coll Dublin Conway Neurosci Investigator, Dublin, Ireland

[8] Med Univ Silesia, Dept Neurol, Katowice, Poland

[9] Jagiellonian Univ, Dept Neurol, Coll Med, Krakow, Poland

[10] Polish Acad Sci, Med Res Ctr, Dept Neurodegenerat Disorders, Warsaw, Poland

[11] MSWiA Hosp, Dept Neurol, Warsaw, Poland

[12] Mayo Clin, Dept Neurol, Coll Med, Jacksonville, FL 32224 USA

来源：

EUROPEAN JOURNAL OF NEUROLOGY | 2010年 / 17卷 / 02期

基金：

瑞士国家科学基金会;

关键词：

association study; calbindin-1; genetics; Parkinson's disease; ALPHA-SYNUCLEIN; CALCIUM; GENE; SUSCEPTIBILITY; DEGENERATION; DOPAMINE; NEURONS; MONKEYS; INFLUX; RISK;

D O I：

10.1111/j.1468-1331.2009.02769.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Background and purpose. Calcium levels have been proposed to play an important role in the selective vulnerability of nigrostriatal dopaminergic neurons in Parkinson's disease (PD). Recently, an association was reported between the calcium buffer, calbindin (rs1805874) and risk of PD in a Japanese patient-control series. Methods: We genotyped rs1805874 in four independent Caucasian patient-control series (1543 PD patients, 1771 controls). Results: There was no evidence of an association between rs1805874 and disease risk in individual populations or in the combined series (odds ratio: 1.04, 95% CI: 0.82-1.31, P = 0.74). Conclusions: Our study shows there is no association between rs1805874 and risk for PD in four Caucasian populations. This suggests the effect of calbindin on PD risk displays population specificity.

引用

页码：208 / 211

页数：4

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