The TCF7L2 Gene Polymorphisms and the Relationship between TCF7L2 Gene and Type 2 Diabetes: A review

被引：0
|
作者：
Zhang Zhong [1 ]
Xie Yue [1 ]
Gao Zhi-Mou [1 ]
机构：
[1] Maoming Univ, Coll Chem & Life Sci, Maoming 525000, Peoples R China
来源：
PROCEEDINGS OF 2009 INTERNATIONAL CONFERENCE OF NATURAL PRODUCT AND TRADITIONAL MEDICINE, VOLS 1 AND 2 | 2009年
关键词：
type; 2; diabetes; TCF7L2; rs7903146; rs12255372; mechanism; INSULIN-SECRETION; RISK; VARIANTS; WNT; ASSOCIATION; PROINSULIN; EXPRESSION; SUSCEPTIBILITY; REPLICATION; MECHANISMS;
D O I：
暂无
中图分类号：
R [医药、卫生];
学科分类号：
10 ;
摘要：
Emerging evidence indicates that,variation in the transcription factor 7-like 2(TCF7L2) gene may play a role in the pathogenesis of type 2 diabetes. The paper was to focus on review the polymorphisms of transcription factor 7-like-2 (TCF7L2) and the possible mechanism that TCF7L2 causes type 2 diabetes. The genetic effects of TCF7L2 have been replicated with remarkable consistency across various populations and stand out as having by far the biggest effect on diabetes risk. There are five single nucleotide polymorphisms (SNPs) of TCF7L2 connecting with Type 2 diabetes, especially the two SNPs (rs7903146 and rs12255372), which have been confirmed in many experiments. The possible mechanism that TCF7L2 causes type 2 diabetes may help to treat and restrain type 2 diabetes.
引用
收藏
页码：377 / 383
页数：7
相关论文
共 50 条
  • [21] Refinement of the association between the TCF7L2 gene and type 2 diabetes in a West African population
    Grant, S. F. A.
    Thorleifsson, G.
    Helgason, A.
    Adeyemo, A.
    Chen, Y.
    Chen, G.
    Benediktsson, R.
    Faruque, M.
    Doumatey, A.
    Zhou, J.
    Thorsteinsdottir, U.
    Gulcher, J. R.
    Kong, A.
    Rotimi, C.
    Stefansson, K.
    DIABETOLOGIA, 2006, 49 : 16 - 17
  • [22] Association between type 2 diabetes mellitus and TCF7L2 gene variant in the Pakistani cohort
    Afira Waqar
    Bushra Chaudhry
    Ikram-ul Haq
    Kausar Saboohi
    Muhammad Nauman Aftab
    Ali Nawaz
    International Journal of Diabetes in Developing Countries, 2023, 43 : 807 - 815
  • [23] The Diabetes Gene TCF7L2 Regulates Adipocyte Development and Metabolism
    Chen, Xi
    Fourcaudot, Marcel
    Bakewell, Terry Slater
    Defronzo, Ralph A.
    Norton, Luke
    DIABETES, 2017, 66 : A472 - A472
  • [24] TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy
    Cinzia Ciccacci
    Davide Di Fusco
    Laura Cacciotti
    Roberto Morganti
    Cinzia D’Amato
    Giuseppe Novelli
    Federica Sangiuolo
    Vincenza Spallone
    Paola Borgiani
    Acta Diabetologica, 2013, 50 : 789 - 799
  • [25] Association between type 2 diabetes mellitus and TCF7L2 gene variant in the Pakistani cohort
    Waqar, Afira
    Chaudhry, Bushra
    Ikram-ul Haq
    Saboohi, Kausar
    Aftab, Muhammad Nauman
    Nawaz, Ali
    INTERNATIONAL JOURNAL OF DIABETES IN DEVELOPING COUNTRIES, 2023, 43 (05) : 807 - 815
  • [26] TCF7L2 gene polymorphisms and type 2 diabetes: association with diabetic retinopathy and cardiovascular autonomic neuropathy
    Ciccacci, Cinzia
    Di Fusco, Davide
    Cacciotti, Laura
    Morganti, Roberto
    D'Amato, Cinzia
    Novelli, Giuseppe
    Sangiuolo, Federica
    Spallone, Vincenza
    Borgiani, Paola
    ACTA DIABETOLOGICA, 2013, 50 (05) : 789 - 799
  • [27] Association of TCF7L2 gene polymorphisms with susceptibility to type 2 diabetes mellitus in a Chinese Hui population
    Yang, Y.
    Xu, J. R.
    Wang, Y. J.
    Liu, X. M.
    GENETICS AND MOLECULAR RESEARCH, 2015, 14 (03) : 10064 - 10071
  • [28] Significant Association of Polymorphisms in the TCF7L2 Gene with a Higher Risk of Type 2 Diabetes in a Moroccan Population
    Elhourch, Sarah
    Arrouchi, Housna
    Mekkaoui, Nour
    Allou, Younes
    Ghrifi, Fatima
    Allam, Loubna
    Elhafidi, Naima
    Belyamani, Lahcen
    Ibrahimi, Azeddine
    Elomri, Naoual
    Eljaoudi, Rachid
    JOURNAL OF PERSONALIZED MEDICINE, 2021, 11 (06):
  • [29] Analysis of TCF7L2, a candidate gene for type 2 diabetes, in Oklahoma American Indians
    Ozga, A. T.
    Lewis, C. M., Jr.
    Obregon, A.
    Tito, R. Y.
    Foster, M. W.
    Stephens, L. D.
    Warren, D. M.
    AMERICAN JOURNAL OF HUMAN BIOLOGY, 2011, 23 (02) : 271 - 271
  • [30] An alternative effector gene at the type 2 diabetes-associated TCF7L2 locus?
    van de Bunt, Martijn
    DIABETOLOGIA, 2016, 59 (11) : 2292 - 2294
12345