Effect of dietary lutein and zeaxanthin on plasma carotenoids and their transport in lipoproteins in age-related macular degeneration

被引:99
作者
Wang, Wei
Connor, Sonja L.
Johnson, Elizabeth J.
Klein, Michael L.
Hughes, Shannon
Connor, William E.
机构
[1] Oregon Hlth & Sci Univ, Dept Med, Portland, OR 97239 USA
[2] Oregon Hlth & Sci Univ, Dept Ophthalmol, Portland, OR 97239 USA
[3] Oregon Hlth & Sci Univ, Ophthalmol Casey Eye Inst, Portland, OR 97239 USA
[4] Tufts Univ, Jean Mayer US Dept Agr, Human Nutr Res Ctr Aging, Boston, MA 02111 USA
关键词
HDL cholesterol; LDL cholesterol; VLDL cholesterol; retina age; macular degeneration;
D O I
10.1093/ajcn/85.3.762
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: Low dietary intakes and low plasma concentrations of lutein and zeaxanthin are associated with an increased risk of age-related macular degeneration (AMD). No studies have challenged AMD patients with a diet high in lutein and zeaxanthin. Objective: The objective was to examine the effect of diets low or high in lutein and zeaxanthin on plasma carotenoids and their transport in AMD patients. Design: Seven AMD patients and 5 control subjects were fed a low-lutein, low-zeaxanthin diet (approximate to 1.1 mg/d) for 2 wk, which was followed by a high-lutein, high-zeaxanthin diet (approximate to 11 mg/d) for 4 wk. Ten subjects continued the diet for 8 wk. Plasma and lipoprotein carotenoids were measured by HPLC. Results: The high-lutein, high-zeaxanthin diet resulted in 2- to 3-fold increases in plasma concentrations of lutein and zeaxanthin and other carotenoids, except lycopene, in the AMD patients and the control subjects. With this diet, 52% of the lutein and 44% of the zeaxanthin were transported by HDL; approximate to 22% of lutein and zeaxanthin was transported by LDL. Only 20-25% of alpha-carotene, beta-carotene, and lycopene was transported by HDL; 50-57% was transported by LDL. Conclusions: The AMD patients and control subjects responded similarly to a diet high in lutein and zeaxanthin; plasma carotenoid concentrations increased greatly in both groups, and the transport of carotenoids by lipoproteins was not significantly different between the groups. This finding suggests that abnormalities in the metabolism of lutein and zeaxanthin in AMD may reside in the uptake of lutein and zeaxanthin from the plasma and transport into the retina.
引用
收藏
页码:762 / 769
页数:8
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