Vanillin mitigates potassium bromate-induced molecular, biochemical and histopathological changes in the kidney of adult mice

被引：15

作者：

Ben Saad, Hajer ^{[1
]}

Driss, Dorra ^{[2
]}

Chaabouni, Samia Ellouz ^{[2
]}

Boudawara, Tahia ^{[3
]}

Zeghal, Khaled Mounir ^{[1
]}

Hakim, Ahmed ^{[1
]}

Ben Amara, Ibtissem ^{[4
]}

机构：

[1] Univ Sfax, Fac Med, Pharmacol Lab, UR 12 ES 13, Sfax 3029, Tunisia

[2] Univ Sfax, Natl Engn Sch, Enzymes & Bioconvers Lab, BP 1173, Sfax 3038, Tunisia

[3] Univ Sfax, Habib Bourguiba Univ Hosp, Anatomopathol Lab, Sfax 3029, Tunisia

[4] Sfax Univ, Higher Inst Biotechnol Sfax, Sfax 3000, Tunisia

来源：

CHEMICO-BIOLOGICAL INTERACTIONS | 2016年 / 252卷

关键词：

Vanillin; Potassium bromate; Metallothionein; Genes expression; Antioxidant activity; ANTIOXIDANT ACTIVITY; OXIDATIVE STRESS; RAT-LIVER; ACID; METALLOTHIONEIN; GLUTATHIONE; INDUCTION; MECHANISM; MALONDIALDEHYDE; BIOMARKERS;

D O I：

10.1016/j.cbi.2016.04.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The present study aimed to explore the ability of vanillin to ameliorate the adverse effects induced by potassium bromate (KBrO3) in the renal tissue. Our results showed a significant increase in hydrogen peroxide, superoxide anion, malondialdehyde, advanced oxidation protein product and protein carbonyl levels in the kidney of KBrO3 treated mice, compared with the control group. Nephrotoxicity was evidenced by a decrease in plasma uric acid and kidney glutathione levels, Na+-K+-ATPase, lactate dehydrogenase and catalase activities. Additionally, creatinine and urea levels significantly increased in the plasma and declined in the urine. Also, Kidney glutathione peroxidase, superoxide dismutase, metallothionein (MT1 and MT2) mRNA expression remarkably increased. These modifications in biochemical and molecular values were substantiated by histopathological data. Co-treatment with vanillin restored these parameters to near control values. Interestingly, vanillin proved to possess, in vitro, a stronger scavenging radical activity than vitamin C and Trolox. Thus, vanillin inhibited KBrO3-induced damage via its antioxidant and antiradical activities as well as its capacity to protect genes expression and histopathological changes. (C) 2016 Elsevier Ireland Ltd. All rights reserved.

引用

页码：102 / 113

页数：12