Team Building: Electronic Management-Clinical Translational Research (eM-CTR) Systems

被引：4

作者：

Cecchetti, Alfred A. ^{[1
]}

Parmanto, Bambang ^{[1
]}

Vecchio, Marcella L. ^{[1
]}

Ahmad, Sjarif ^{[1
]}

Buch, Shama ^{[1
]}

Zgheib, Nathalie K. ^{[1
]}

Groark, Stephen J., Jr. ^{[1
]}

Vemuganti, Anupama ^{[1
]}

Romkes, Marjorie ^{[1
]}

Sciurba, Frank ^{[2
]}

Donahoe, Michael P. ^{[2
]}

Branch, Robert A. ^{[1
]}

机构：

[1] Univ Pittsburgh, Ctr Clin Pharmacol, Pittsburgh, PA 15260 USA

[2] Dept Med, Div Pulm Med, Pittsburgh, PA USA

来源：

CTS-CLINICAL AND TRANSLATIONAL SCIENCE | 2009年 / 2卷 / 06期

关键词：

institutional management teams; organization and administration; information services; information storage and retrieval;

D O I：

10.1111/j.1752-8062.2009.00157.x

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Classical drug exposure: response studies in clinical pharmacology represent the quintessential prototype for Bench to Bedside-Clinical Translational Research. A fundamental premise of this approach is for a multidisciplinary team of researchers to design and execute complex, in-depth mechanistic studies conducted in relatively small groups of subjects. The infrastructure support for this genre of clinical research is not well-handled by scaling down of infrastructure used for large Phase III clinical trials. We describe a novel, integrated strategy, whose focus is to support and manage a study using an Information Hub, Communication Hub, and Data Hub design. This design is illustrated by an application to a series of varied projects sponsored by Special Clinical Centers of Research in chronic obstructive pulmonary disease at the University of Pittsburgh. In contrast to classical informatics support, it is readily scalable to large studies. Our experience suggests the culture consequences of research group self-empowerment is not only economically efficient but transformative to the research process.

引用

页码：449 / 455

页数：7