Multiscale Control of Hierarchical Structure in Crystalline Block Copolymer Nanoparticles Using Microfluidics

被引：25

作者：

Bains, Aman ^{[1
]}

Cao, Yimeng ^{[1
]}

Moffitt, Matthew G. ^{[1
]}

机构：

[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada

来源：

MACROMOLECULAR RAPID COMMUNICATIONS | 2015年 / 36卷 / 22期

基金：

加拿大自然科学与工程研究理事会;

关键词：

block copolymers; drug delivery; microfluidics; nanoparticles; self-assembly; POLYMERIC MICELLES; DRUG-DELIVERY; MULTIPLE MORPHOLOGIES; FLOW; FILOMICELLES; PACLITAXEL; VESICLES; CARRIERS; SHAPE; PCL;

D O I：

10.1002/marc.201500359

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas-liquid microfluidic reactor with top-down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate length scales by a single control variable (flow rate) enables tailoring of drug delivery nanoparticle function including release rates.

引用

页码：2000 / 2005

页数：6

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