Multiscale Control of Hierarchical Structure in Crystalline Block Copolymer Nanoparticles Using Microfluidics

被引：25
作者：
Bains, Aman [1 ]
Cao, Yimeng [1 ]
Moffitt, Matthew G. [1 ]
机构：
[1] Univ Victoria, Dept Chem, Victoria, BC V8W 3V6, Canada
来源：
MACROMOLECULAR RAPID COMMUNICATIONS | 2015年 / 36卷 / 22期
基金：
加拿大自然科学与工程研究理事会;
关键词：
block copolymers; drug delivery; microfluidics; nanoparticles; self-assembly; POLYMERIC MICELLES; DRUG-DELIVERY; MULTIPLE MORPHOLOGIES; FLOW; FILOMICELLES; PACLITAXEL; VESICLES; CARRIERS; SHAPE; PCL;
D O I：
10.1002/marc.201500359
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Hierarchical semicrystalline block copolymer nanoparticles are produced in a segmented gas-liquid microfluidic reactor with top-down control of multiscale structural features, including nanoparticle morphologies, sizes, and internal crystallinities. Control of multiscale structure on disparate length scales by a single control variable (flow rate) enables tailoring of drug delivery nanoparticle function including release rates.
引用
收藏
页码：2000 / 2005
页数：6
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