Metallic entities with quiet a heavier molecular weight have been a part of environment with a subtle existence, but their haphazard use for mankind purposes has amended the natures balance in two of the ways, whether it may be biochemical or geochemical. Outcome front these activity speaks loudly about their excess release in the form nickel, zinc cadmium, copper, had, and others into the environment. Exposure with them for longer durations and with hugely growing accumulation rates portrays deleterious effects on aquatic forms of life as well as human life forms. Microorganisms with their versatile metabolic activities are somehow indulged in their remediation this has been well studied and implemented till now. The present review is an attempt to scrutinize the capability of microorganisms and as well as plants to remediate the compilation of heavy metals. In accordance to build up a referable literature this review will also show insight to physical and chemical ways. A microorganism when studied at the molecular level gives insight that they accumulate heavy metals and denigrate them at their sites where they are present. The present literature and work review will discuss benevolent strategies to tackle compilations of heavy metals. Microbial life forms which are used for the removal of heavy metals from the water bodies include bacteria, fungi, algae and yeast. Some important antioxidants such as flavonoids, pectin and phytic acid are also used for the elimination of the heavy metals from the human body. The present article is an extensive review that will offer a number of strategies and possible mechanisms for the heavy metals removal both from environment as well as from human body.