Bioactive steroids and sorbicillinoids isolated from the endophytic fungus Trichoderma sp Xy24

被引：19
|
作者：
Zhao, Jin-Lian [1 ,2 ]
Zhang, Min [1 ,2 ]
Liu, Ji-Mei [1 ,2 ]
Tan, Zhen [1 ,2 ]
Chen, Ri-Dao [1 ,2 ,3 ,4 ,5 ]
Xie, Ke-Bo [1 ,2 ,3 ,4 ,5 ]
Dai, Jun-Gui [1 ,2 ,3 ,4 ,5 ]
机构：
[1] Chinese Acad Med Sci, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China
[2] Peking Union Med Coll, Beijing 100050, Peoples R China
[3] Chinese Acad Med Sci, Key Lab Biosynth Nat Prod, Natl Hlth & Family Planning Commiss, Inst Mat Med, Beijing 100050, Peoples R China
[4] Chinese Acad Med Sci, Beijing Key Lab Nonclin Drug Metab, Beijing 100050, Peoples R China
[5] Chinese Acad Med Sci, Inst Mat Med, PK PD Study, Beijing 100050, Peoples R China
来源：
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2017年 / 19卷 / 10期
关键词：
Steroids; sorbicillinoids; Trichoderma sp; Xy24; anti-HIV activity; anti-inflammatory activity; cytotoxicity; DOWN-REGULATION; FRUIT BODIES; TRICHODIMEROL; CONSTITUENTS; MACROPHAGES; METABOLITES; COMPOUND; ASSAY;
D O I：
10.1080/10286020.2017.1285908
中图分类号：
Q94 [植物学];
学科分类号：
071001 ;
摘要：
A new steroid glucoside (1), along with nine known steroids (2-10) and four known sorbicillinoids (11-14), were isolated from the endophytic fungus Trichoderma sp. Xy24. Their structures were elucidated on the basis of spectroscopic data analyses and by comparison with reported data. Compounds 3, 5-7, 9, 10, and 13 exhibited significant inhibitory effects on HIV-1 virus with IC50 values ranging 1.9-9.3 mu M; compounds 10, 13, and 14 showed potent inhibitory activity on LPS-induced NO production in BV2 microglia cells with inhibitory rates of 108.2, 100, and 75.1% at 10 mu M, respectively. In addition, compound 10 displayed moderate cytotoxicity against BCG823 and HePG2 cell lines with IC50 values of 11.1 and 17.7 mu M, respectively.
引用
收藏
页码：1028 / 1035
页数：8
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