A Cyclooligomerisation Approach to Backbone-Modified Cyclic Peptides Bearing Guanidinium Arms

被引：13

作者：

Black, Richard J. G. ^{[1
]}

Dungan, Victoria J. ^{[1
]}

Li, Rebecca Y. T. ^{[1
]}

Young, Philip G. ^{[1
]}

Jolliffe, Katrina A. ^{[1
]}

机构：

[1] Univ Sydney, Sch Chem, Sydney, NSW 2006, Australia

来源：

SYNLETT | 2010年 / 04期

基金：

澳大利亚研究理事会;

关键词：

peptides; macrocycles; cyclisation; heterocycles; amides; MARINE CYCLOPEPTIDES; STEROID ANTIBIOTICS; CATIONIC PEPTIDE; DENDROAMIDE-A; THIAZOLE; OXAZOLES; CONFIGURATION; HEXAPEPTIDE; RECEPTORS; SCAFFOLDS;

D O I：

10.1055/s-0029-1219155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Cyclooligomerisation of the pentafluorophenyl ester derivatives of oxazoles, derived from dipeptides containing protected ornithine, diaminobutanoic acid and diaminopropionic acid residues, gives the cyclic trimers as the major products. Deprotection and treatment with guanidinylating agents provides efficient access to backbone rigidified cyclic peptides with guanidinium functionalised side chains.

引用

页码：551 / 554

页数：4

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