Making muscle: skeletal myogenesis in vivo and in vitro

被引：609

作者：

Chal, Jerome ^{[1
,2
,3
]}

Pourquie, Olivier ^{[1
,2
,3
,4
]}

机构：

[1] Brigham & Womens Hosp, Dept Pathol, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[2] Harvard Med Sch, Dept Genet, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[3] Harvard Stem Cell Inst, 77 Ave Louis Pasteur, Boston, MA 02115 USA

[4] Univ Strasbourg, Inserm U964, CNRS, IGBMC,UMR 7104, F-67400 Illkirch Graffenstaden, France

来源：

DEVELOPMENT | 2017年 / 144卷 / 12期

基金：

欧洲研究理事会;

关键词：

Skeletal myogenesis; Muscle differentiation; Paraxial mesoderm; Somite; Dermomyotome; Muscular dystrophy; Pluripotent stem cells; Embryonic stem cells; iPS cells; EMBRYONIC STEM-CELLS; BONE MORPHOGENETIC PROTEIN-4; HUMAN INDUCED PLURIPOTENT; FIBROBLAST-GROWTH-FACTOR; BHLH GENE-EXPRESSION; SATELLITE-LIKE CELLS; PARAXIAL MESODERM; MUSCULAR-DYSTROPHY; SOMITE FORMATION; MYOBLAST FUSION;

D O I：

10.1242/dev.151035

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Skeletal muscle is the largest tissue in the body and loss of its function or its regenerative properties results in debilitating musculoskeletal disorders. Understanding the mechanisms that drive skeletal muscle formation will not only help to unravel the molecular basis of skeletal muscle diseases, but also provide a roadmap for recapitulating skeletal myogenesis in vitro from pluripotent stem cells (PSCs). PSCs have become an important tool for probing developmental questions, while differentiated cell types allow the development of novel therapeutic strategies. In this Review, we provide a comprehensive overview of skeletal myogenesis from the earliest premyogenic progenitor stage to terminally differentiated myofibers, and discuss how this knowledge has been applied to differentiate PSCs into muscle fibers and their progenitors in vitro.

引用

页码：2104 / 2122

页数：19

共 349 条

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