Efficient syncope prediction from resting state clinical data using wavelet bispectrum and multilayer perceptron neural network

Neurally mediated syncope (NMS) is the most common type of syncope, and head up tilt test (HUTT) is, so far, the most appropriate tool to identify NMS. In this work, an effort to predict the NMS before performing the HUTT is attempted. To achieve this, the heart rate variability (HRV) at rest and during the first minutes of tilting position during HUTT was analyzed using both time and frequency domains. Various features from HRV regularity and complexity, along with wavelet higher-order spectrum (WHOS) analysis in low-frequency (LF) and high-frequency (HF) bands were examined. The experimental results from 26 patients with history of NMS have shown that at rest, a time domain entropy measure and WHOS-based features in LF band exhibit significant differences between positive and negative HUTT as well as among 10 healthy subjects and NMS patients. The best performance of multilayer perceptron neural network (MPNN) was achieved by using an input vector consisted of WHOS-based HRV features in the LF zone and systolic blood pressure from the resting period, yielding an accuracy of 89.7%, assessed by 5-fold cross-validation. The promising results presented here pave the way for an early prediction of the HUTT outcome from resting state, contributing to the identification of patients at higher risk NMS. The HRV analysis along with systolic blood pressure at rest predict NMS using a multilayer perceptron neural network.