Chemokines in lymphocyte trafficking and intestinal immunity

被引：160
作者：
Kunkel, EJ
Campbell, DJ
Butcher, EC
机构：
[1] Stanford Univ, Sch Med, Dept Pathol, Lab Immunol & Vasc Biol, Stanford, CA 94305 USA
[2] Vet Affairs Palo Alto Hlth Care Syst, Ctr Mol Biol & Med, Palo Alto, CA USA
来源：
MICROCIRCULATION | 2003年 / 10卷 / 3-4期
关键词：
CCL25; CCL28; IgA; GALT; homing;
D O I：
10.1038/sj.mn.7800196
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Lymphocyte migration through gut-associated lymphoid tissues (GALT) and into intestinal effector sites is critical to intestinal immune system function and homeostasis. Chemokines contribute to lymphocyte trafficking by triggering integrin activation and firm arrest in the vasculature and mediating chemotactic localization within tissues. Several chemokines have been identified that are expressed in the GALT and/or the intestines themselves (TECK/CCL25, MEC/CCL28, and MIP-3alpha/CCL20) and play a role in intestinal lymphocyte localization, including unification of intestinal and other mucosa-associated effector sites; segmental specialization of the intestines; and subset selective localization to the intestines. This review examines the role of these chemokines ( and their receptors CCR9, CCR10, and CCR6, respectively) in lymphocyte homing to the GALT, in the induction and differentiation of intestinal effector and memory lymphocytes, and in the homeostatic and inflammatory localization of lymphocytes to the intestines.
引用
收藏
页码：313 / 323
页数：11
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