Epigenetic Mechanisms: Role in Hematopoietic Stem Cell Lineage Commitment and Differentiation

被引：16

作者：

Raghuwanshi, Sanjeev ^{[1
]}

Dahariya, Swati ^{[1
]}

Kandi, Ravinder ^{[1
]}

Gutti, Usha ^{[2
]}

Undi, Ram Babu ^{[1
]}

Sharma, Durga Shankar ^{[1
]}

Sahu, Itishri ^{[1
]}

Kovuru, Narasaiah ^{[1
]}

Yarla, Nagendra Sastry ^{[2
]}

Saladi, Raja Gopal Venakata ^{[2
]}

Gutti, Ravi Kumar ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Life Sci, Dept Biochem, Stem Cells & Haematol Disorders Lab, PO Gachibowli, Hyderabad 500046, TS, India

[2] GITAM Univ, GITAM Inst Sci, Visakhapatnam 530045, Andhra Prades, India

来源：

CURRENT DRUG TARGETS | 2018年 / 19卷 / 14期

关键词：

Epigenetics; hematopoietic stem cell (HSC); DNA methylation; histones; miRNA; acetyltransferases (HATs); DNA methyltransferases; DNA METHYLATION; SELF-RENEWAL; DE-NOVO; 5-METHYLCYTOSINE OXIDATION; HISTONE MODIFICATIONS; NERVOUS-SYSTEM; NUCLEAR EXPORT; MAMMALIAN DNA; TET PROTEINS; CXXC DOMAIN;

D O I：

10.2174/1389450118666171122141821

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Major breakthroughs in the last several decades have contributed to our knowledge of the genetic regulation in development. Although epigenetics is not a new concept, unfortunately, the role of epigenetics has not come to fruition in the past. But the field of epigenetics has exploded within the past decade. Now, growing evidences show a complex network of epigenetic regulation in development. The epigenetic makeup of a cell, tissue or individual is much more complex than their genetic complement. Epigenetic modifications are more important for normal development by maintaining the gene expression pattern in tissue-and context-specific manner. Deregulation of epigenetic mechanism can lead to altered gene expression and its function, which result in altered tissue specific function of cells and malignant transformation. Epigenetic modifications directly shape Hematopoietic Stem Cell (HSC) developmental cascades, including their maintenance of self-renewal and multilineage potential, lineage commitment, and aging. Hence, there is a growing admiration for epigenetic players and their regulatory function in haematopoiesis. Epigenetic mechanisms underlying these modifications in mammalian genome are still not completely understood. This review mainly explains 3 key epigenetics mechanisms including DNA methylation, histone modifications and non-coding RNAs inference in hematopoietic lineage commitment and differentiation.

引用

页码：1683 / 1695

页数：13

共 144 条

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