Emerging therapies for pulmonary arterial hypertension

被引:10
作者
Ali, Omar [1 ]
Wharton, John [1 ]
Simon, John [1 ]
Gibbs, Russell [1 ]
Howard, Luke [1 ]
Wilkins, Martin Russell [1 ]
机构
[1] Univ London Imperial Coll Sci & Technol, Hammersmith Hosp, London W12 0NN, England
关键词
pulmonary arterial hypertension; vascular remodelling;
D O I
10.1517/13543784.16.6.803
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Pulmonary arterial hypertension is characterised by increased pulmonary vascular resistance due to increased vascular tone and structural remodelling of pulmonary vessels. The therapies that are in use so far have been developed to correct endothelial dysfunction and reduce vasomotor tone. These treatments have a limited effect on the remodelling process and, increasingly, the focus is turning to potent strategies for inhibiting vascular proliferation and promoting vascular apoptosis. Multiple novel targets have been uncovered over the last 5 years and several are now in early clinical trials. At present, it is clear that there is no single treatment for the condition. Although this is the case, studies are investigating the role of combining therapies that are already established.
引用
收藏
页码:803 / 818
页数:16
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