Cage-like monoterpenoid indole alkaloids with antimicrobial activity from Alstonia scholaris

被引：24

作者：

Yu, Hao-Fei ^{[1
,2
,3
,5
]}

Huang, Wan-Yi ^{[4
]}

Ding, Cai-Feng ^{[1
,5
]}

Wei, Xin ^{[1
,5
]}

Zhang, Lan-Chun ^{[2
,3
]}

Qin, Xu-Jie ^{[1
]}

Ma, Hong-Xia ^{[4
]}

Yang, Zi-Feng ^{[4
]}

Liu, Ya-Ping ^{[1
]}

Zhang, Rong-Ping ^{[2
,3
]}

Wang, Xin-Hua ^{[4
]}

Luo, Xiao-Dong ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Yunnan, Peoples R China

[2] Kunming Med Univ, Sch Pharmaceut Sci, Dept Zool, Kunming 650500, Yunnan, Peoples R China

[3] Kunming Med Univ, Yunnan Key Lab Pharmacol Nat Prod, Kunming 650500, Yunnan, Peoples R China

[4] Guangzhou Med Univ, State Key Lab Resp Dis, Guangzhou 510120, Guangdong, Peoples R China

[5] Univ Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

TETRAHEDRON LETTERS | 2018年 / 59卷 / 31期

关键词：

Alstonia scholaris; lndole alkaloids; Scholarisine; Antimicrobial activities; (+)-SCHOLARISINE; LEAVES; DITERPENOIDS;

D O I：

10.1016/j.tetlet.2018.06.047

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three new cage-like monoterpenoid indole alkaloids, scholarisines T-V (1-3), together with three known analogues 4-6 were isolated from the leaves of Alstonia scholaris. Among them, 2 represents a unique degraded derivative, whereas 3 shares a rare 5,16-seco lactone scaffold. The structures were mainly established by extensive spectroscopic data analyses, and their plausible biosynthesis pathway from picrinine were proposed. Compared with positive control cefotaxime, alkaloid 2 showed remarkable antibacterial activity against Bacillus subtilis with an MIC value of 3.12 mu g/mL, whereas 1-3 exhibited significant antibacterial effects on Escherichia coli with an MIC value of 0.78 mu g/mL. (C) 2018 Published by Elsevier Ltd.

引用

页码：2975 / 2978

页数：4

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