γ-Lactam alkaloids from the flower buds of daylily

被引：25

作者：

Matsumoto, Takahiro ^{[1
]}

Nakamura, Seikou ^{[1
]}

Nakashima, Souichi ^{[1
]}

Ohta, Tomoe ^{[1
]}

Yano, Mamiko ^{[1
]}

Tsujihata, Junichiro ^{[1
]}

Tsukioka, Junko ^{[1
]}

Ogawa, Keiko ^{[1
]}

Fukaya, Masashi ^{[1
]}

Yoshikawa, Masayuki ^{[1
]}

Matsuda, Hisashi ^{[1
]}

机构：

[1] Kyoto Pharmaceut Univ, Dept Pharmacognosy, Yamashina Ku, Kyoto 6078412, Japan

来源：

JOURNAL OF NATURAL MEDICINES | 2016年 / 70卷 / 03期

基金：

日本学术振兴会;

关键词：

Daylily; Alkaloids; Alzheimer's diseases; PC12; cell; A beta 42 aggregation; OLEANANE-TYPE; 2,5-DIHYDROFURYL-GAMMA-LACTAM DERIVATIVES; TRITERPENE OLIGOGLYCOSIDES; CANANGA-ODORATA; ADENOSINE; C-13;

D O I：

10.1007/s11418-015-0963-z

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new alkaloids, hemerocallisamines IV-VII, were isolated from the methanol extract of flower buds of daylily. The chemical structures of the new compounds were elucidated on the basis of chemical and physicochemical evidence. The absolute stereochemistry of the hemerocallisamines IV-VI was elucidated by the application of the modified Mosher's method, HPLC analysis, and optical rotation. In the present study, the isolated alkaloids significantly inhibited the aggregation of A beta 42 in vitro. This is the first report about bioactive alkaloids with a gamma-lactam ring from daylily. In addition, isolated nucleosides showed accelerative effects on neurite outgrowth under the non-fasting condition.

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收藏

页码：376 / 383

页数：8

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