Practice Summary of Antimicrobial Therapy for Commonly Encountered Conditions in the Neonatal Intensive Care Unit: A Canadian Perspective

被引：19

作者：

Ting, Joseph Y. ^{[1
,2
]}

Autmizguine, Julie ^{[3
,4
]}

Dunn, Michael S. ^{[5
]}

Choudhury, Julie ^{[6
]}

Blackburn, Julie ^{[7
]}

Gupta-Bhatnagar, Shikha ^{[8
]}

Assen, Katrin ^{[2
]}

Emberley, Julie ^{[9
]}

Khan, Sarah ^{[10
]}

Leung, Jessica ^{[11
]}

Lin, Grace J. ^{[12
]}

Lu-Cleary, Destiny ^{[13
]}

Morin, Frances ^{[2
]}

Richter, Lindsay L. ^{[2
]}

Viel-Theriault, Isabelle ^{[14
]}

Roberts, Ashley ^{[2
]}

Lee, Kyong-soon ^{[5
]}

Skarsgard, Erik D. ^{[15
]}

Robinson, Joan ^{[16
]}

Shah, Prakesh S. ^{[5
]}

机构：

[1] Univ Alberta, Dept Pediat, Edmonton, AB, Canada

[2] Univ British Columbia, Dept Pediat, Vancouver, BC, Canada

[3] Univ Montreal, Dept Pediat, Div Infect Dis, Montreal, PQ, Canada

[4] Univ Montreal, Dept Pharmacol & Physiol, Montreal, PQ, Canada

[5] Univ Toronto, Dept Pediat, Div Neonatol, Toronto, ON, Canada

[6] Sunnybrook Hlth Sci Ctr, Dept Pharm, Toronto, ON, Canada

[7] Univ Montreal, Dept Microbiol Infect Dis & Immunol, Montreal, PQ, Canada

[8] McMaster Univ, Dept Pediat, Div Neonatol, Hamilton, ON, Canada

[9] Univ Manitoba, Dept Pediat, Div Neonatol, Winnipeg, MB, Canada

[10] McMaster Univ, Dept Microbiol, Hamilton, ON, Canada

[11] Univ Massachusetts, Dept Pediat, Worcester, MA 01605 USA

[12] Queens Univ, Sch Med, Kingston, ON, Canada

[13] Northern Ontario Sch Med, Thunder Bay, ON, Canada

[14] Univ Laval, Dept Pediat, Div Infect Dis, CHU Quebec, Quebec City, PQ, Canada

[15] Univ British Columbia, Dept Surg, Div Pediat Surg, Vancouver, BC, Canada

[16] Univ Alberta, Dept Pediat, Div Infect Dis, Edmonton, AB, Canada

来源：

FRONTIERS IN PEDIATRICS | 2022年 / 10卷

基金：

加拿大健康研究院;

关键词：

neonate; sepsis; urinary tract infection; surgical prophylaxis; ventilator-associated pneumonia; necrotizing enterocolitis; antimicrobial; VENTILATOR-ASSOCIATED PNEUMONIA; URINARY-TRACT-INFECTION; BIRTH-WEIGHT INFANTS; EARLY-ONSET SEPSIS; EMPIRICAL ANTIBIOTIC-TREATMENT; CLINICAL-PRACTICE GUIDELINES; EXTREMELY PREMATURE-INFANTS; RANDOMIZED CONTROLLED-TRIAL; SURGICAL SITE INFECTIONS; B STREPTOCOCCAL DISEASE;

D O I：

10.3389/fped.2022.894005

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Neonates are highly susceptible to infections owing to their immature cellular and humoral immune functions, as well the need for invasive devices. There is a wide practice variation in the choice and duration of antimicrobial treatment, even for relatively common conditions in the NICU, attributed to the lack of evidence-based guidelines. Early decisive treatment with broad-spectrum antimicrobials is the preferred clinical choice for treating sick infants with possible bacterial infection. Prolonged antimicrobial exposure among infants without clear indications has been associated with adverse neonatal outcomes and increased drug resistance. Herein, we review and summarize the best practices from the existing literature regarding antimicrobial use in commonly encountered conditions in neonates.

引用

页数：19

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