Stereoselective neuroimaging in vivo

被引：7

作者：

Smith, Donald F. ^{[1
]}

Jakobsen, Steen

机构：

[1] Univ Aarhus, Hosp Psychiat, Ctr Psychiat Res, Risskov 8240, Denmark

[2] Aarhus Univ Hosp, PET Ctr, DK-8000 Aarhus, Denmark

来源：

EUROPEAN NEUROPSYCHOPHARMACOLOGY | 2007年 / 17卷 / 08期

关键词：

positron emission tomography; single photon emission tomography; PET; SPECT; receptor; brain imaging; pharmacokinetics; neuroreceptor ligands; radiolabeled enantiomers; stereosetective neurotransmission;

D O I：

10.1016/j.euroneuro.2007.02.008

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Stereoselectivity is a basic property of many neuronal processes due to the spatial features of molecules involved in neurotransmission. Today, neuroimaging procedures are available for studying stereoselectivity in the living brain. Mirror-image radiotracers are the molecular tools that are used, together with single photon emission tomography (SPECT) and positron emission tomography (PET), for studying stereoselective neuronat mechanisms. This review presents the findings obtained in those studies of chotinergic, noradrenergic, dopaminergic, serotonergic, glutamatergic, opioid, cannabinoid, and second messenger neurotransmission. (c) 2007 Elsevier B.V. and ECNP. All rights reserved.

引用

页码：507 / 522

页数：16

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