Multiparametric MR Imaging Features of Primary CNS Lymphomas

被引:4
作者
Talybov, Rustam
Beylerli, Ozal
Mochalov, Vadim
Prokopenko, Alexey
Ilyasova, Tatiana
Trofimova, Tatiana
Sufianov, Albert
Guang, Yang
机构
[1] Federal Center of Neurosurgery, Tyumen
[2] Bashkir State Medical University, Ufa
[3] V.M. Bekhterev Psychoneurological Research Institute, St. Petersburg
[4] Department of Neurosurgery, Sechenov First Moscow State Medical University (Sechenov University), Moscow
[5] Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin
[6] Institute of Brain Science, Harbin Medical University, Harbin
来源
FRONTIERS IN SURGERY | 2022年 / 9卷
关键词
CT; MRI; neuroradiology; perfusion; PCNSL; NERVOUS-SYSTEM LYMPHOMAS; DIFFUSION-COEFFICIENT VALUES; CEREBRAL BLOOD-VOLUME; PERFUSION; CT; GLIOMA;
D O I
10.3389/fsurg.2022.887249
中图分类号
R61 [外科手术学];
学科分类号
摘要
ObjectivePrimary central nervous system lymphomas (PCNS) are relatively rare tumors, accounting for about 4% of all brain tumors. On neuroimaging, they are characterized by a low MR signal in T1, isointense in T2, bright uniform contrast enhancement, and diffusion restriction. The aim of this study is to note the lack of effectiveness of the MR/CT perfusion technique in complex multiparametric imaging in the differential diagnosis of primary lymphomas of the central nervous system in comparison with highly malignant gliomas and brain metastases. Materials and MethodsThis prospective study included 80 patients with CNS tumors examined/operated at the Federal Center for Neurosurgery (Tyumen, Russia) from 2018 to 2021. The patients were divided into 4 groups: group 1 consisted of 33 cases with primary CNS lymphomas (10 cases with atypical manifestations according to perfusion parameters and 23 cases of classic CNS lymphomas), group 2 with anaplastic astrocytomas-14 cases, group 3-23 cases with glioblastomas and group 4-10 cases with solitary metastatic lesions. The study was carried out on a General Electric Discovery W750 3T magnetic resonance tomograph, a Canon Aquilion One multispiral X-ray computed tomograph (Gadovist 7.5 ml, Yomeron 400 mg-50 ml). Additionally, immunohistochemical analysis was carried out with the following markers: CD3, CD20, CD34, Ki-67, VEGF. ResultsIt has been established that MR/CT perfusion is not a highly sensitive method for visualizing primary CNS lymphomas, as previously thought, but at the same time, the method has a number of undeniable advantages that make it indispensable in the algorithm of a complex multiparametric diagnostic approach for this type of tumor. Nevertheless, PLCNS is characterized by an atypical manifestation, which is an exception to the rule. ConclusionsThe possibilities of neuroimaging of primary lymphomas, even with the use of improved techniques for collecting MR/CT data, are limited and do not always allow reliable differentiation from other neoplasms.
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页数:12
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