Effect of flexing and massage on in vivo human skin penetration and toxicity of zinc oxide nanoparticles

被引：47

作者：

Leite-Silva, Vania R. ^{[1
,2
]}

Liu, David C. ^{[1
]}

Sanchez, Washington Y. ^{[1
]}

Studier, Hauke ^{[5
]}

Mohammed, Yousuf H. ^{[1
]}

Holmes, Amy ^{[5
]}

Becker, Wolfgang ^{[4
]}

Grice, Jeffrey E. ^{[1
]}

Benson, Heather A. E. ^{[3
]}

Roberts, Michael S. ^{[1
,5
]}

机构：

[1] Univ Queensland, Translat Res Inst, Sch Med, Therapeut Res Ctr, Woolloongabba, Qld, Australia

[2] Univ Fed Sao Paulo, Inst Ciencias Ambientais Quim & Farmaceut, Diadema, SP, Brazil

[3] Curtin Univ Technol, CHIRI, Sch Pharm, Perth, WA, Australia

[4] Becker & Hickl GmbH, Nahmitzer Damm 30, D-12277 Berlin, Germany

[5] Univ S Australia, Sch Pharm & Med Sci, City East Campus, Adelaide, SA 5001, Australia

来源：

NANOMEDICINE | 2016年 / 11卷 / 10期

基金：

英国医学研究理事会;

关键词：

flexing; human skin in vivo; imaging; massage; nanoparticle penetration; zinc oxide; FLUORESCENCE LIFETIME; ZNO NANOPARTICLES; VIABLE EPIDERMIS; HAIR-FOLLICLES; DRUG-DELIVERY; DNA-DAMAGE; CELLS; SUNSCREEN; VITRO; KERATINOCYTES;

D O I：

10.2217/nnm-2016-0010

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Aim: We assessed the effects of flexing and massage on human skin penetration and toxicity of topically applied coated and uncoated zinc oxide nanoparticles (similar to 75 nm) in vivo. Materials & methods: Noninvasive multiphoton tomography with fluorescence lifetime imaging was used to evaluate the penetration of nanoparticles through the skin barrier and cellular apoptosis in the viable epidermis. Results: All nanoparticles applied to skin with flexing and massage were retained in the stratum corneum or skin furrows. No significant penetration into the viable epidermis was seen and no cellular toxicity was detected. Conclusion: Exposure of normal in vivo human skin to these nanoparticles under common in-use conditions of flexing or massage is not associated with significant adverse events.

引用

页码：1193 / 1205

页数：13

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