Potent tumor-directed T cell activation and tumor inhibition induced by ALG.APV-527, a 4-1BB x 5T4 ADAPTIR™ bispecific antibody

被引:0
|
作者
Nelson, Michelle H. [1 ]
Miller, Robert [1 ]
Bader, Robert [1 ]
Werchau, Doreen [2 ]
Nilsson, Anneli [2 ]
Ljung, Lill [2 ]
Deronic, Adnan [2 ]
Chunyk, Allison [1 ]
Schultz, Lena [2 ]
McMahan, Catherine [1 ]
Bienvenue, David [1 ]
Dahlman, Anna [2 ]
Fritzell, Sara [2 ]
Askmyr, Maria [1 ]
Hernandez-Hoyos, Gabriela [1 ]
机构
[1] Aptevo Therapeut Inc, Seattle, WA USA
[2] Alligator Biosci AB, Lund, Sweden
来源
关键词
D O I
暂无
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
P642
引用
收藏
页数:2
相关论文
共 50 条
  • [31] Activation of anti-tumor NK cells by gamma delta T lymphocytes through 4-1BB engagement
    Chapoval, Andrei
    Maniar, Amudhan
    Zhang, Xiaoyu
    Gastman, Brian R.
    Pauza, C. David
    Strome, Scott E.
    JOURNAL OF IMMUNOLOGY, 2009, 182
  • [32] Combination CTLA-4 Blockade and 4-1BB Activation Enhances Tumor Rejection by Increasing T-Cell Infiltration, Proliferation, and Cytokine Production
    Curran, Michael A.
    Kim, Myoungjoo
    Montalvo, Welby
    Al-Shamkhani, Aymen
    Allison, James P.
    PLOS ONE, 2011, 6 (04):
  • [33] HBM7008, A FIRST-IN-CLASS BISPECIFIC ANTIBODY TARGETING BOTH B7-H4 AND 4-1BB, EXHIBITS ROBUST ANTI-TUMOR IMMUNITY AND LOW TOXICITY THROUGH B7-H4-DIRECTED 4-1BB ACTIVATION
    Huang, Bing
    Du, Fangfang
    Lv, Xiaocheng
    Zhao, Jianxun
    Chen, Fei
    Lu, Zailian
    Zhang, Yang
    Chen, Victor
    Gan, Xin
    Zhao, Jiuqiao
    He, Yun
    Wu, Xiaodong
    Rong, Yiping
    JOURNAL FOR IMMUNOTHERAPY OF CANCER, 2022, 10 : A1099 - A1099
  • [34] Divergent effects of 4-1BB antibodies on antitumor immunity and on tumor-reactive T-cell generation
    Kim, JA
    Averbook, BJ
    Chambers, K
    Rothchild, K
    Kjaergaard, J
    Papay, R
    Shu, SY
    CANCER RESEARCH, 2001, 61 (05) : 2031 - 2037
  • [35] The bispecific antibody KA-3002, targeting PSMA and 4-1BB, specifically enhances T cell activity within prostate tumors
    Wu, Guojin
    Liang, Jiabei
    Peng, Hao
    Hao, Feng
    Liu, Tongtong
    Ning, Jinying
    CANCER RESEARCH, 2024, 84 (06)
  • [36] Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
    Timothy S. Fisher
    Cris Kamperschroer
    Theodore Oliphant
    Victoria A. Love
    Paul D. Lira
    Regis Doyonnas
    Simon Bergqvist
    Sangita M. Baxi
    Allison Rohner
    Amy C. Shen
    Chunli Huang
    Sharon A. Sokolowski
    Leslie L. Sharp
    Cancer Immunology, Immunotherapy, 2012, 61 : 1721 - 1733
  • [37] Targeting of 4-1BB by monoclonal antibody PF-05082566 enhances T-cell function and promotes anti-tumor activity
    Fisher, Timothy S.
    Kamperschroer, Cris
    Oliphant, Theodore
    Love, Victoria A.
    Lira, Paul D.
    Doyonnas, Regis
    Bergqvist, Simon
    Baxi, Sangita M.
    Rohner, Allison
    Shen, Amy C.
    Huang, Chunli
    Sokolowski, Sharon A.
    Sharp, Leslie L.
    CANCER IMMUNOLOGY IMMUNOTHERAPY, 2012, 61 (10) : 1721 - 1733
  • [38] Preclinical pharmacology of MP0310: A 4-1BB/FAP bispecific DARPin drug candidate promoting tumor-restricted T-cell costimulation
    Link, Alexander
    Hepp, Julia
    Reichen, Christian
    Schildknecht, Patricia
    Tosevski, Ivana
    Taylor, Joanna
    Juglair, Laurent
    Titz, Alexander
    Matzner, Mirela
    Bessey, Ralph
    Zitt, Christof
    Lemaillet, Guy
    Herbst, Joerg
    Dawson, Keith M.
    Ji, Hong
    Levitsky, Victor
    Snell, Dan
    Stumpp, Michael T.
    Harstrick, Andreas
    vom Baur, Elmar
    CANCER RESEARCH, 2018, 78 (13)
  • [39] BCG016, a first-in-class bispecific antibody-drug conjugate targeting 5T4 and MUC1, demonstrates potent preclinical anti-tumor activity
    Han, Zhenyan
    Shang, Chengzhang
    Zhang, Yifu
    An, Gao
    Guo, Chaoshe
    An, W. Frank
    Yang, Yi
    CANCER RESEARCH, 2024, 84 (06)
  • [40] Simultaneous costimulatory T-cell engagement and checkpoint inhibition by PRS-344/S095012, a PD-L1 / 4-1BB bispecific compound for tumor localized activation of the immune system.
    Morales-Kastresana, Aizea
    Pavlidou, Marina
    Peper, Janet
    Pattarini, Lucia
    Barthels, Christian
    Hansbauer, Eva-Maria
    Aiba, Rachida Bel
    Bossenmaier, Birgit
    Scholer-Dahirel, Alix
    Jaquin, Thomas
    Gallou, Catherine
    Blanc, Veronique
    Rothe, Christine
    Olwill, Shane
    CANCER RESEARCH, 2021, 81 (13)