Low Central Nervous System Posaconazole Concentrations during Cerebral Phaeohyphomycosis

被引：21

作者：

Barde, Francois ^{[1
]}

Billaud, Eliane ^{[2
]}

Goldwirt, Lauriane ^{[3
]}

Horodyckid, Catherine ^{[4
]}

Jullien, Vincent ^{[2
]}

Lanternier, Fanny ^{[1
,5
]}

Lesprit, Philippe ^{[6
]}

Limousin, Lucie ^{[7
]}

Cohen, Jeremie F. ^{[1
]}

Lortholary, Olivier ^{[1
,5
]}

机构：

[1] Paris Descartes Univ, Necker Enfants Malades Hosp, AP HP, Necker Pasteur Ctr Infect Dis & Trop Med, Paris, France

[2] Paris Descartes Univ, European Hosp Georges Pompidou, AP HP, Lab Pharmacol & Toxicol, Paris, France

[3] Univ Paris Diderot, St Louis Hosp, AP HP, Dept Pharmacol, Paris, France

[4] Foch Hosp, Dept Neurosurg, Suresnes, France

[5] CNRS, Natl Reference Ctr Invas Mycoses & Antifungals, Mol Mycol Unit, Inst Pasteur,UMR 2000, Paris, France

[6] Foch Hosp, Dept Clin Biol, Suresnes, France

[7] Foch Hosp, Dept Microbiol, Suresnes, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2019年 / 63卷 / 11期

关键词：

invasive fungal infections; antifungal therapy; plasma drug levels; therapeutic drug monitoring; Rhinocladiella mackenziei; cerebral phaeohyphomycosis; ITRACONAZOLE; PENETRATION; MACKENZIEI; THERAPY;

D O I：

10.1128/AAC.01184-19

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Posaconazole diffusion has been documented in various organs, which contrasts with the scarce data available for the human central nervous system (CNS). We analyzed posaconazole concentrations in plasma and multiple CNS specimens taken from a patient who received posaconazole because of cerebral phaeohyphomycosis. Low posaconazole concentrations were obtained in CNS specimens, with sample-to-plasma ratios between 5% and 22%. This case highlights the role of neurosurgery during cerebral phaeohyphomycoses, even those caused by posaconazole-susceptible black fungi.

引用

页数：4

共 13 条

[1] Successful therapy of cerebral phaeohyphomycosis due to Ramichloridium mackenziei with the new triazole posaconazole [J].

Al-Abdely, HM ;

Alkhunaizi, AM ;

Al-Tawfiq, JA ;

Hassounah, M ;

Rinaldi, MG ;

Sutton, DA .

MEDICAL MYCOLOGY, 2005, 43 (01) :91-95

[2] Posaconazole Concentrations in Human Tissues after Allogeneic Stem Cell Transplantation [J].

Blennow, Ola ;

Eliasson, Erik ;

Pettersson, Tommy ;

Pohanka, Anton ;

Szakos, Attila ;

El-Serafi, Ibrahim ;

Hassan, Moustapha ;

Ringden, Olle ;

Mattsson, Jonas .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2014, 58 (08) :4941-4943

[3] Murine Model of a Disseminated Infection by the Novel Fungus Fonsecaea monophora and Successful Treatment with Posaconazole [J].

Calvo, Enrique ;

Javier Pastor, F. ;

Mar Rodriguez, M. ;

Mayayo, Emilio ;

Salas, Valentina ;

Guarro, Josep .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 2010, 54 (02) :919-923

[4] Posaconazole vs. fluconazole or itraconazole prophylaxis in patients with neutropenia [J].

Cornely, Oliver A. ;

Maertens, Johan ;

Winston, Drew J. ;

Perfect, John ;

Ullmann, Andrew J. ;

Walsh, Thomas J. ;

Helfgott, David ;

Holowiecki, Jerzy ;

Stockelberg, Dick ;

Goh, Yeow-Tee ;

Petrini, Mario ;

Hardalo, Cathy ;

Suresh, Ramachandran ;

Angulo-Gonzalez, David .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 356 (04) :348-359

[5] Cerebral Phaeohyphomycosis Caused by Rhinocladiella mackenziei in a Woman Native to Afghanistan [J].

Cristini, Alejandro ;

Garcia-Hermoso, Dea ;

Celard, Marie ;

Albrand, Gilles ;

Lortholary, Olivier .

JOURNAL OF CLINICAL MICROBIOLOGY, 2010, 48 (09) :3451-3454

[6] Tissue Penetration of Antifungal Agents [J].

Felton, Timothy ;

Troke, Peter F. ;

Hope, William W. .

CLINICAL MICROBIOLOGY REVIEWS, 2014, 27 (01) :68-88

[7] Treatment of Refractory Coccidioidomycosis With Voriconazole or Posaconazole [J].

Kim, Michelle M. ;

Vikram, Holenarasipur R. ;

Kusne, Shimon ;

Seville, Maria Teresa ;

Blair, Janis E. .

CLINICAL INFECTIOUS DISEASES, 2011, 53 (11) :1060-1066

[8] P-glycoprotein-mediated transport of itraconazole across the blood-brain barrier [J].

Miyama, T ;

Takanaga, H ;

Matsuo, H ;

Yamano, K ;

Yamamoto, K ;

Iga, T ;

Naito, M ;

Tsuruo, T ;

Ishizuka, H ;

Kawahara, Y ;

Sawada, Y .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1998, 42 (07) :1738-1744

[9] Activity of posaconazole in the treatment of central nervous system fungal infections [J].

Pitisuttithum, P ;

Negroni, R ;

Graybill, JR ;

Bustamante, B ;

Pappas, P ;

Chapman, S ;

Hare, RS ;

Hardalo, CJ .

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY, 2005, 56 (04) :745-755

[10] Limited penetration of posaconazole into cerebrospinal fluid in an allogeneic stem cell recipient with invasive pulmonary aspergillosis [J].

Reinwald, M. ;

Uharek, L. ;

Lampe, D. ;

Grobosch, T. ;

Thiel, E. ;

Schwartz, S. .

BONE MARROW TRANSPLANTATION, 2009, 44 (04) :269-270

← 1 2 →