Two enabling architectures for DNA-templated organic synthesis

被引:82
作者
Gartner, ZJ [1 ]
Grubina, R [1 ]
Calderone, CT [1 ]
Liu, DR [1 ]
机构
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
关键词
bioorganic chemistry; combinatorial chemistry; DNA; template synthesis;
D O I
10.1002/anie.200390351
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
Reactivity can be rationally manipulated in DNA-templated synthesis by altering the design of template architectures: a) The omega (Ω) architecture enables DNA-templated reactions to be encoded by bases distal from the reactive end of the template, regardless of the distance dependence of the reaction. b) The T architecture enables two DNA-templated reactions to take place on a single template in one solution, as illustrated.
引用
收藏
页码:1370 / 1375
页数:6
相关论文
共 53 条
[1]   Chemical amplification (CHAMP) by a continuous, self-replicating oligonucleotide-based system [J].
Albagli, D ;
Van Atta, R ;
Cheng, P ;
Huan, BF ;
Wood, ML .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1999, 121 (29) :6954-6955
[2]   Recent advances in the in vitro evolution of nucleic acids [J].
Bittker, JA ;
Phillips, KJ ;
Liu, DR .
CURRENT OPINION IN CHEMICAL BIOLOGY, 2002, 6 (03) :367-374
[3]   TEMPLATE SWITCHING BETWEEN PNA AND RNA OLIGONUCLEOTIDES [J].
BOHLER, C ;
NIELSEN, PE ;
ORGEL, LE .
NATURE, 1995, 376 (6541) :578-581
[4]   SELF-INCORPORATION OF COENZYMES BY RIBOZYMES [J].
BREAKER, RR ;
JOYCE, GF .
JOURNAL OF MOLECULAR EVOLUTION, 1995, 40 (06) :551-558
[5]   Template-directed ligation of peptides to oligonucleotides [J].
Bruick, RK ;
Dawson, PE ;
Kent, SB ;
Usman, N ;
Joyce, GF .
CHEMISTRY & BIOLOGY, 1996, 3 (01) :49-56
[6]  
Calderone C. T., 2002, ANGEW CHEM, V114, P4278
[7]  
Calderone CT, 2002, ANGEW CHEM INT EDIT, V41, P4104, DOI 10.1002/1521-3773(20021104)41:21<4104::AID-ANIE4104>3.0.CO
[8]  
2-O
[9]   Nucleic acid template-directed assembly of metallosalen-DNA conjugates [J].
Czlapinski, JL ;
Sheppard, TL .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2001, 123 (35) :8618-8619
[10]   OLIGONUCLEOTIDE CIRCULARIZATION BY TEMPLATE-DIRECTED CHEMICAL LIGATION [J].
DOLINNAYA, NG ;
BLUMENFELD, M ;
MERENKOVA, IN ;
ORETSKAYA, TS ;
KRYNETSKAYA, NF ;
IVANOVSKAYA, MG ;
VASSEUR, M ;
SHABAROVA, ZA .
NUCLEIC ACIDS RESEARCH, 1993, 21 (23) :5403-5407