The predictive link between matrix and metastasis

被引：27

作者：

Barney, L. E. ^{[1
]}

Jansen, L. E. ^{[1
]}

Polio, S. R. ^{[1
]}

Galarza, S. ^{[1
]}

Lynch, M. E. ^{[1
,2
]}

Peyton, S. R. ^{[1
]}

机构：

[1] Univ Massachusetts, Dept Chem Engn, Amherst, MA 01003 USA

[2] Univ Massachusetts, Dept Mech & Ind Engn, Amherst, MA 01003 USA

来源：

CURRENT OPINION IN CHEMICAL ENGINEERING | 2016年 / 11卷

关键词：

BREAST-CANCER METASTASIS; EPITHELIAL-MESENCHYMAL TRANSITION; IN-VITRO MODEL; EXTRACELLULAR-MATRIX; BRAIN METASTASES; CELL-MIGRATION; TUMOR; TISSUE; NICHE; CARCINOMA;

D O I：

10.1016/j.coche.2016.01.001

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Cancer spread (metastasis) is responsible for 90% of cancer-related fatalities. Informing patient treatment to prevent metastasis, or kill all cancer cells in a patient's body before it becomes metastatic is extremely powerful. However, aggressive treatment for all non-metastatic patients is detrimental, both for quality of life concerns, and the risk of kidney or liver-related toxicity. Knowing when and where a patient has metastatic risk could revolutionize patient treatment and care. In this review, we attempt to summarize the key work of engineers and quantitative biologists in developing strategies and model systems to predict metastasis, with a particular focus on cell interactions with the extracellular matrix (ECM), as a tool to predict metastatic risk and tropism.

引用

页码：85 / 93

页数：9

共 82 条

[1] Chromosomal copy number alterations for associations of ductal carcinoma in situ with invasive breast cancer [J].

Afghahi, Anosheh ;

Forgo, Erna ;

Mitani, Aya A. ;

Desai, Manisha ;

Varma, Sushama ;

Seto, Tina ;

Rigdon, Joseph ;

Jensen, Kristin C. ;

Troxell, Megan L. ;

Gomez, Scarlett Lin ;

Das, Amar K. ;

Beck, Andrew H. ;

Kurian, Allison W. ;

West, Robert B. .

BREAST CANCER RESEARCH, 2015, 17

[2] Targeting dormant cancer [J].

Aguirre-Ghiso, Julio A. ;

Bragado, Paloma ;

Sosa, Maria Soledad .

NATURE MEDICINE, 2013, 19 (03) :276-277

[3] A physical sciences network characterization of non-tumorigenic and metastatic cells [J].

Agus, David B. ;

Alexander, Jenolyn F. ;

Arap, Wadih ;

Ashili, Shashanka ;

Aslan, Joseph E. ;

Austin, Robert H. ;

Backman, Vadim ;

Bethel, Kelly J. ;

Bonneau, Richard ;

Chen, Wei-Chiang ;

Chen-Tanyolac, Chira ;

Choi, Nathan C. ;

Curley, Steven A. ;

Dallas, Matthew ;

Damania, Dhwanil ;

Davies, Paul C. W. ;

Decuzzi, Paolo ;

Dickinson, Laura ;

Estevez-Salmeron, Luis ;

Estrella, Veronica ;

Ferrari, Mauro ;

Fischbach, Claudia ;

Foo, Jasmine ;

Fraley, Stephanie I. ;

Frantz, Christian ;

Fuhrmann, Alexander ;

Gascard, Philippe ;

Gatenby, Robert A. ;

Geng, Yue ;

Gerecht, Sharon ;

Gillies, Robert J. ;

Godin, Biana ;

Grady, William M. ;

Greenfield, Alex ;

Hemphill, Courtney ;

Hempstead, Barbara L. ;

Hielscher, Abigail ;

Hillis, W. Daniel ;

Holland, Eric C. ;

Ibrahim-Hashim, Arig ;

Jacks, Tyler ;

Johnson, Roger H. ;

Joo, Ahyoung ;

Katz, Jonathan E. ;

Kelbauskas, Laimonas ;

Kesselman, Carl ;

King, Michael R. ;

Konstantopoulos, Konstantinos ;

Kraning-Rush, Casey M. ;

Kuhn, Peter .

SCIENTIFIC REPORTS, 2013, 3

[4] Epithelial mesenchymal transition in early invasive breast cancer: an immunohistochemical and reverse phase protein array study [J].

Aleskandarany, Mohammed A. ;

Negm, Ola H. ;

Green, Andrew R. ;

Ahmed, Mohamed A. H. ;

Nolan, Christopher C. ;

Tighe, Patrick J. ;

Ellis, Ian O. ;

Rakha, Emad A. .

BREAST CANCER RESEARCH AND TREATMENT, 2014, 145 (02) :339-348

[5] A cell-ECM screening method to predict breast cancer metastasis [J].

Barney, L. E. ;

Dandley, E. C. ;

Jansen, L. E. ;

Reich, N. G. ;

Mercurio, A. M. ;

Peyton, S. R. .

INTEGRATIVE BIOLOGY, 2015, 7 (02) :198-212

[6] The independent roles of mechanical, structural and adhesion characteristics of 3D hydrogels on the regulation of cancer invasion and dissemination [J].

Beck, Jennifer N. ;

Singh, Anirudha ;

Rothenberg, Ashley R. ;

Elisseeff, Jennifer H. ;

Ewald, Andrew J. .

BIOMATERIALS, 2013, 34 (37) :9486-9495

[7] A microfluidic 3D in vitro model for specificity of breast cancer metastasis to bone [J].

Bersini, Simone ;

Jeon, Jessie S. ;

Dubini, Gabriele ;

Arrigoni, Chiara ;

Chung, Seok ;

Charest, Joseph L. ;

Moretti, Matteo ;

Kamm, Roger D. .

BIOMATERIALS, 2014, 35 (08) :2454-2461

[8] Acellular Normal and Fibrotic Human Lung Matrices as a Culture System for In Vitro Investigation [J].

Booth, Adam J. ;

Hadley, Ryan ;

Cornett, Ashley M. ;

Dreffs, Alyssa A. ;

Matthes, Stephanie A. ;

Tsui, Jessica L. ;

Weiss, Kevin ;

Horowitz, Jeffrey C. ;

Fiore, Vincent F. ;

Barker, Thomas H. ;

Moore, Bethany B. ;

Martinez, Fernando J. ;

Niklason, Laura E. ;

White, Eric S. .

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2012, 186 (09) :866-876

[9] Genes that mediate breast cancer metastasis to the brain [J].

Bos, Paula D. ;

Zhang, Xiang H. -F. ;

Nadal, Cristina ;

Shu, Weiping ;

Gomis, Roger R. ;

Nguyen, Don X. ;

Minn, Andy J. ;

van de Vijver, Marc J. ;

Gerald, William L. ;

Foekens, John A. ;

Massague, Joan .

NATURE, 2009, 459 (7249) :1005-U137

[10] Physical and chemical microenvironmental cues orthogonally control the degree and duration of fibrosis-associated epithelial-to-mesenchymal transitions [J].

Brown, Ashley C. ;

Fiore, Vincent F. ;

Sulchek, Todd A. ;

Barker, Thomas H. .

JOURNAL OF PATHOLOGY, 2013, 229 (01) :25-35

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