Retinal Fractals and Acute Lacunar Stroke

被引：93

作者：

Cheung, Ning ^{[2
]}

Liew, Gerald ^{[3
,4
]}

Lindley, Richard I. ^{[5
]}

Liu, Erica Y. ^{[1
]}

Wang, Jie Jin ^{[2
,3
,4
]}

Hand, Peter ^{[6
]}

Baker, Michelle ^{[2
]}

Mitchell, Paul ^{[3
,4
]}

Wong, Tien Y. ^{[1
,2
]}

机构：

[1] Natl Univ Singapore, Singapore Eye Res Inst, Yong Loo Lin Sch Med, Singapore 168751, Singapore

[2] Univ Melbourne, Ctr Eye Res Australia, Royal Victorian Eye & Ear Hosp, Melbourne, Vic, Australia

[3] Univ Sydney, Ctr Vis Res, Dept Ophthalmol, Sydney, NSW 2006, Australia

[4] Univ Sydney, Westmead Millennium Inst, Sydney, NSW 2006, Australia

[5] Univ Sydney, Western Clin Sch, Sydney, NSW 2006, Australia

[6] Royal Melbourne Hosp, Melbourne, Vic, Australia

来源：

ANNALS OF NEUROLOGY | 2010年 / 68卷 / 01期

基金：

英国医学研究理事会;

关键词：

DIABETIC-RETINOPATHY; MICROVASCULAR SIGNS; VESSELS; VASCULOGENESIS; RISK;

D O I：

10.1002/ana.22011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

This study aimed to determine whether retinal fractal dimension, a quantitative measure of microvascular branching complexity and density, is associated with lacunar stroke. A total of 392 patients presenting with acute ischemic stroke had retinal fractal dimension measured from digital photographs, and lacunar infarct ascertained from brain imaging. After adjusting for age, gender, and vascular risk factors, higher retinal fractal dimension (highest vs lowest quartile and per standard deviation increase) was independently and positively associated with lacunar stroke (odds ratio [OR], 4.27; 95% confidence interval [CI], 1.49-12.17 and OR, 1.85; 95% CI, 1.20-2.84, respectively). Increased retinal microvascular complexity and density is associated with lacunar stroke. ANN NEUROL 2010;68:107-111

引用

页码：107 / 111

页数：5

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