Protein tyrosine phosphatase PTPN22 in human autoimmunity

被引：128
|
作者：
Vang, Torkel
Miletic, Ana V.
Bottini, Nunzio
Mustelin, Tomas
机构：
[1] Burnham Inst Med Res, La Jolla, CA 92037 USA
[2] Univ So Calif, Inst Med Genet, Keck Sch Med, Los Angeles, CA 90033 USA
[3] Amgen Inc, Seattle, WA 98119 USA
来源：
AUTOIMMUNITY | 2007年 / 40卷 / 06期
关键词：
protein tyrosine phosphatase; human autoimmunity; Graves' disease; rheumatoid arthritis; type; 1; diabetes;
D O I：
10.1080/08916930701464897
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
The discovery that a single-nucleotide polymorphism ( SNP) in lymphoid tyrosine phosphatase (LYP), encoded by the PTPN22 gene, is associated with type 1 diabetes (T1D) has now been verified by numerous studies and has been expanded to rheumatoid arthritis, juvenile rheumatoid arthritis (JRA), systemic lupus erythematosus, Graves' disease, generalized vitiligo and other human autoimmune diseases. In this paper, we discuss the association of PTPN22 with autoimmunity, the biochemistry of the PTPN22-encoded phosphatase, and the molecular mechanism(s) by which the disease-predisposing allele contributes to the development of human disease.
引用
收藏
页码：453 / 461
页数：9
相关论文
共 50 条
  • [1] Roles of the protein tyrosine phosphatase PTPN22 in immunity and autoimmunity
    Fousteri, Georgia
    Liossis, Stamatis-Nick C.
    Battaglia, Manuela
    CLINICAL IMMUNOLOGY, 2013, 149 (03) : 556 - 565
  • [2] The putative role of the C1858T polymorphism of protein tyrosine phosphatase PTPN22 gene in autoimmunity
    Gianchecchi, Elena
    Palombi, Melania
    Fierabracci, Alessandra
    AUTOIMMUNITY REVIEWS, 2013, 12 (07) : 717 - 725
  • [3] Tyrosine Phosphatase PTPN22: Multifunctional Regulator of Immune Signaling, Development, and Disease
    Bottini, Nunzio
    Peterson, Erik J.
    ANNUAL REVIEW OF IMMUNOLOGY, VOL 32, 2014, 32 : 83 - 119
  • [4] NLRP3 tyrosine phosphorylation is controlled by protein tyrosine phosphatase PTPN22
    Spalinger, Marianne R.
    Kasper, Stephanie
    Gottier, Claudia
    Lang, Silvia
    Atrott, Kirstin
    Vavricka, Stephan R.
    Scharl, Sylvie
    Gutte, Petrus M.
    Grutter, Markus G.
    Beer, Hans-Dietmar
    Contassot, Emmanuel
    Chan, Andrew C.
    Dai, Xuezhi
    Rawlings, David J.
    Mair, Florian
    Becher, Burkhard
    Falk, Werner
    Fried, Michael
    Rogler, Gerhard
    Scharl, Michael
    JOURNAL OF CLINICAL INVESTIGATION, 2016, 126 (05) : 1783 - 1800
  • [5] Association of Functional Polymorphism in Protein Tyrosine Phosphatase Nonreceptor 22 (PTPN22) Gene with Vitiligo
    Bin Huraib, Ghaleb
    Al Harthi, Fahad
    Arfin, Misbahul
    Aljamal, Abdulrahman
    Alrawi, Abdulqader Saeed
    Al-Asmari, Abdulrahman
    BIOMARKER INSIGHTS, 2020, 15
  • [6] PTPN22: Setting thresholds for autoimmunity
    Gregersen, Peter K.
    Lee, Hye-Soon
    Batliwalla, Franak
    Begovich, Ann B.
    SEMINARS IN IMMUNOLOGY, 2006, 18 (04) : 214 - 223
  • [7] C1858T Polymorphism of Protein Tyrosine Phosphatase Non-receptor Type 22 (PTPN22): an eligible target for prevention of type 1 diabetes?
    Prezioso, Giovanni
    Comegna, Laura
    Di Giulio, Concetta
    Franchini, Simone
    Chiarelli, Francesco
    Blasetti, Annalisa
    EXPERT REVIEW OF CLINICAL IMMUNOLOGY, 2017, 13 (03) : 189 - 196
  • [8] The protein tyrosine phosphatase PTPN22 negatively regulates presentation of immune complex derived antigens
    Clarke, Fiona
    Purvis, Harriet A.
    Sanchez-Blanco, Cristina
    Gutierrez-Martinez, Enrique
    Cornish, Georgina H.
    Zamoyska, Rose
    Guermonprez, Pierre
    Cope, Andrew P.
    SCIENTIFIC REPORTS, 2018, 8
  • [9] Susceptibility influence of a PTPN22 haplotype with thyroid autoimmunity in Koreans
    Lee, Hye-Soon
    Kang, Jungoo
    Yang, Seiwon
    Kim, Dukhee
    Park, Yongsoo
    DIABETES-METABOLISM RESEARCH AND REVIEWS, 2011, 27 (08) : 878 - 882
  • [10] Lymphoid tyrosine phosphatase (LYP/PTPN22) Arg620Trp variant regulates insulin autoimmunity and progression to type 1 diabetes
    Hermann, R
    Lipponen, K
    Kiviniemi, M
    Kakko, T
    Veijola, R
    Simell, O
    Knip, M
    Ilonen, J
    DIABETOLOGIA, 2006, 49 (06) : 1198 - 1208
12345