Polysaccharide based bionanocomposite hydrogels reinforced with cellulose nanocrystals: Drug release and biocompatibility analyses

被引：66
作者：
Rao, Kummara Madhusudana [1 ]
Kumar, Anuj [1 ]
Han, Sung Soo [1 ]
机构：
[1] Yeungnam Univ, Sch Chem Engn, 280 Daehak Ro, Kyongsan 712749, South Korea
来源：
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES | 2017年 / 101卷
关键词：
Cellulose nanocrystals; Bionanocomposite; Hydrogels; Drug release; Biocompatibility; POLYELECTROLYTE COMPLEX; CHITOSAN; XANTHAN; SCAFFOLDS; COMPOSITE; GELS; GUM;
D O I：
10.1016/j.ijbiomac.2017.03.080
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cellulose nanocrystals (CNCs) reinforced, bionanocomposite (BNC) has shown great potential in tissue engineering and drug delivery applications due to the low toxicity, low density, and high aspect ratio. In this work, BNC hydrogels reinforced with CNCs were fabricated from xanthan (XG) solutions and chitosan (CS) in presence of green acidifying agent through electrostatic and hydrogen bonding interactions. As developed BNC hydrogels were characterized for complex formation, morphology, and mechanical behavior. The mechanical performance of BNC hydrogels was improved significantly as increased CNC content (from 2 to lOwt%). 5-Flurouracil as model chemotherapeutic agent was loaded into these BNC hydrogels for evaluating their drug release properties. The BNC hydrogels showed excellent cytocompatability and ability to release of chemotherapeutic agent that shows the suitability to be used in tissue engineering as well as drug delivery applications. (C) 2017 Elsevier B.V. All rights reserved.
引用
收藏
页码：165 / 171
页数：7
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