Genetics of focal segmental glomerulosclerosis

被引：32
|
作者：
Woroniecki, Robert P.
Kopp, Jeffrey B.
机构：
[1] Childrens Hosp, Bronx, NY 10467 USA
[2] Albert Einstein Coll Med, Bronx, NY 10467 USA
[3] NIDDKD, Kidney Dis Sect, NIH, Dept Hlth & Human Serv, Bethesda, MD 20892 USA
来源：
PEDIATRIC NEPHROLOGY | 2007年 / 22卷 / 05期
关键词：
gene mutations; filtration barrier; linkage analysis; positional cloning;
D O I：
10.1007/s00467-007-0445-y
中图分类号：
R72 [儿科学];
学科分类号：
100202 ;
摘要：
The recent advances in understanding the pathophysiology of focal segmental glomerulosclerosis (FSGS) and molecular function of glomerular filtration barrier come directly from genetic linkage and positional cloning studies. The exact role and function of the newly discovered genes and proteins are being investigated by in vitro and in vivo mechanistic studies. Those genes and proteins interactions seem to change susceptibility to kidney disease progression. Better understanding of their exact role in the development of FSGS may influence future therapies and outcomes in this complex disease.
引用
收藏
页码：638 / 644
页数：7
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