Neuroimaging Through the Course of Alzheimer's Disease

被引：17
|
作者：
Smith, Charles D. [1 ]
机构：
[1] Univ Kentucky, Rush Alzheimers Dis Ctr, Sanders Brown Ctr Aging,Chandler Med Ctr, Dept Neurol,Magnet Resonance Imaging & Spect Ctr, Lexington, KY 40536 USA
来源：
JOURNAL OF ALZHEIMERS DISEASE | 2010年 / 19卷 / 01期
基金：
美国国家卫生研究院;
关键词：
Alzheimer's disease; computed tomography; diffusion tensor imaging; FDG; functional imaging; human; magnetic resonance imaging; mild cognitive impairment; morphometry; PIB; positron emission tomography; prediction; review; MILD COGNITIVE IMPAIRMENT; VOXEL-BASED MORPHOMETRY; POSITRON-EMISSION-TOMOGRAPHY; WHITE-MATTER DAMAGE; MEDIAL TEMPORAL ATROPHY; DIFFUSION-TENSOR; BRAIN ATROPHY; DEFAULT-MODE; HIPPOCAMPAL ATROPHY; AMYLOID DEPOSITION;
D O I：
10.3233/JAD-2010-1217
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This review uses an image-indexed framework for the full course of Alzheimer's disease (AD) to provide a perspective on recent neuroimaging findings in the literature. Modalities considered include morphometric, diffusion tensor, and functional magnetic resonance imaging, and resting/functional metabolic and amyloid-label positron emission tomography. The major focus is on the AD pre-states (normal but high AD risk and mild cognitive impairment), and transition from mild cognitive impairment to mild AD. Imaging results relevant to the conduct of future prevention and early intervention trials are emphasized.
引用
收藏
页码：273 / 290
页数：18
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