Oxidative Stress Modulation by Rosmarinus officinalis in CCl4-induced Liver Cirrhosis

被引:37
作者
Gutierrez, Rosalinda [1 ]
Alvarado, Jose L. [1 ]
Presno, Manuel [1 ]
Perez-Veyna, Oscar [1 ]
Serrano, Carmen J. [1 ]
Yahuaca, Patricia [1 ]
机构
[1] Univ Autonoma Zacatecas, Unidad Acad Med Humana, Zacatecas 98000, Mexico
关键词
Rosmarinus officinalis; antioxidative hepatoprotection; cirrhosis; carbon tetrachloride; lipoperoxidation; CARBON-TETRACHLORIDE; ANTIOXIDANT PROPERTIES; LIPID-PEROXIDATION; CARNOSIC ACID; IN-VITRO; ROSEMARY; EXTRACTS; RATS; HEPATOTOXICITY; DITERPENES;
D O I
10.1002/ptr.2997
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Rosmarinus officinalis (Lamiaceae) possesses antioxidant activity and hepatoprotective effects, and so may provide a possible therapeutic alternative for chronic liver disease. The effect produced by a methanolic extract of Rosmarinus officinalis on CCI4-induced liver cirrhosis in rats was investigated using both prevention and reversion models. Over the course of the development of cirrhosis, the increased enzymatic activities of gammaglutamyl transpeptidase and alanine aminotransferase, and the rise in bilirubin levels caused by CCl4 administration, were prevented by Rosmurinus officinalis co-administration. When the cirrhosis by oxidative stress was evaluated as an increase on liver lipoperoxidation, total lipid peroxides, nitric oxide in serum, and loss of erythrocyte plasma membrane stability, R. officinalis was shown to prevent such alterations. On cirrhotic animals treated with CCl4, histological studies showed massive necrosis, periportal inflammation and fibrosis which were modified by R. officinalis. These benefits on experimental cirrhosis suggest a potential therapeutic use for R. officinalis as an alternative for liver cirrhosis. Copyright (C) 2009 John Wiley & Sons, Ltd.
引用
收藏
页码:595 / 601
页数:7
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