Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

被引：0

作者：

Wunderle, Marius ^{[1
]}

Haeberle, Lothar ^{[1
,2
]}

Hein, Alexander ^{[1
]}

Jud, Sebastian M. ^{[1
]}

Lux, Michael P. ^{[3
]}

Hack, Carolin C. ^{[1
]}

Emons, Julius ^{[1
]}

Heindl, Felix ^{[1
]}

Nabieva, Naiba ^{[1
]}

Loehberg, Christian R. ^{[1
]}

Schulz-Wendtland, Rudiger ^{[4
]}

Hartmann, Arndt ^{[5
]}

Beckmann, Matthias W. ^{[1
]}

Fasching, Peter A. ^{[1
]}

Gass, Paul ^{[1
]}

机构：

[1] Friedrich Alexander Univ Erlangen Nuremberg, Comprehens Canc Ctr Erlangen EMN, Erlangen Univ Hosp, Dept Gynecol & Obstet, Univ Str 21-23, DE-91054 Erlangen, Germany

[2] Friedrich Alexander Univ Erlangen Nuremberg, Dept Gynecol & Obstet, Biostat Unit, Erlangen, Germany

[3] Womens Hosp St Josefs Krankenhaus Salzkotten, Frauen & Kinderklin St Louise, Womens Hosp St Louise Paderborn, Dept Gynecol & Obstet, Paderborn, Germany

[4] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen Univ Hosp, Inst Diagnost Radiol, Erlangen, Germany

[5] Friedrich Alexander Univ Erlangen Nuremberg, Erlangen Univ Hosp, Inst Pathol, Erlangen, Germany

来源：

BREAST CARE | 2021年 / 16卷 / 03期

关键词：

Breast cancer; Ovarian cancer; Family history; Neoadjuvant chemotherapy; Pathological complete response; Prognosis; MUTATION CARRIERS; CLINICAL-OUTCOMES; POOLED ANALYSIS; GENE-MUTATIONS; SURVIVAL; BRCA1; WOMEN; RISK; COHORT; ASSOCIATIONS;

D O I：

10.1159/000507475

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Purpose: In breast cancer, a pathological complete response (pCR) has been described as generally resulting in a favorable prognosis. However, there are subgroups, such as patients with a mutation in BRCA1 or BRCA2,in which the effect of pCR on the prognosis is suspected to be weaker. Patients with a family history of breast and/or ovarian cancer may therefore react differently in relation to pCR and prognosis, and this is investigated in this study. Patients and Methods: Breast cancer patients were identified from a clinical breast cancer registry. The study subjects had been treated with neoadjuvant chemotherapy from 2001 to 2018 and their pathological and clinical information as well as medical family history were available. They were considered to have a positive family history if they had at least 1 first-degree relative with breast and/or ovarian cancer. Multivariate logistic regression analyses were performed to study the association between family history, pCR (ypT0; ypN0), and disease-free survival (DFS). Results: Of 1,480 patients, 228 (15.4%) had a positive family history. The pCR rates were 24.9% in all patients, and 24.4% and 27.6% in those without/with a family history, respectively. Family history was not associated with a higher pCR rate (adjusted odds ratio [OR] 1.23; 95% confidence interval [CI] 0.85-1.76; p = 0.27) or a different disease-free survival (DFS; adjusted hazard ratio [HR] 1.15; 95% CI 0.88-1.52; p = 0.30). pCR did not affect the prognosis differently in relation to family history. Conclusions: In this retrospective analysis, family history was not associated with pCR and DFS. pCR improved survival, independently of family history.

引用

页码：254 / 262

页数：9