A Natural Allele of a Transcription Factor in Rice Confers Broad-Spectrum Blast Resistance

被引：574

作者：

Li, Weitao ^{[1
,2
,7
]}

Zhu, Ziwei ^{[1
,2
,7
]}

Chern, Mawsheng ^{[3
,4
,7
]}

Yin, Junjie ^{[1
,2
,7
]}

Yang, Chao ^{[1
,2
,7
]}

Ran, Li ^{[1
,2
,7
]}

Cheng, Mengping ^{[5
]}

He, Min ^{[1
,2
]}

Wang, Kang ^{[1
,2
]}

Wang, Jing ^{[1
,2
]}

Zhou, Xiaogang ^{[1
,2
]}

Zhu, Xiaobo ^{[1
,2
]}

Chen, Zhixiong ^{[1
,2
]}

Wang, Jichun ^{[1
,2
]}

Zhao, Wen ^{[1
,2
,6
]}

Ma, Bingtian ^{[1
,2
]}

Qin, Peng ^{[1
,2
]}

Chen, Weilan ^{[1
,2
]}

Wang, Yuping ^{[1
,2
]}

Liu, Jiali ^{[1
,2
]}

Wang, Wenming ^{[1
,2
]}

Wu, Xianjun ^{[1
,2
]}

Li, Ping ^{[1
,2
]}

Wang, Jirui ^{[5
]}

Zhu, Lihuang ^{[6
]}

Li, Shigui ^{[1
,2
]}

Chen, Xuewei ^{[1
,2
]}

机构：

[1] Sichuan Agr Univ Wenjiang, Rice Res Inst, Key Lab Major Crop Dis, State Key Lab Hybrid Rice, Chengdu 611130, Sichuan, Peoples R China

[2] Sichuan Agr Univ Wenjiang, Collaborat Innovat Ctr Hybrid Rice Yangtze River, Chengdu 611130, Sichuan, Peoples R China

[3] Univ Calif Davis, Dept Plant Pathol, Davis, CA 95616 USA

[4] Joint Bioenergy Inst, Emeryville, CA 94608 USA

[5] Sichuan Agr Univ, Triticeae Res Inst, Chengdu 611130, Sichuan, Peoples R China

[6] Chinese Acad Sci, Inst Genet & Dev Biol, State Key Lab Plant Genom, Beijing 100101, Peoples R China

[7] Chinese Acad Sci, Natl Ctr Plant Gene Res, Beijing 100101, Peoples R China

来源：

CELL | 2017年 / 170卷 / 01期

基金：

美国国家科学基金会;

关键词：

MAGNAPORTHE-ORYZAE; DISEASE RESISTANCE; DURABLE RESISTANCE; INNATE IMMUNITY; NADPH OXIDASE; ARABIDOPSIS; PLANTS; GENE; PEROXIDASE; DEFENSE;

D O I：

10.1016/j.cell.2017.06.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rice feeds half the world's population, and rice blast is often a destructive disease that results in significant crop loss. Non-race-specific resistance has been more effective in controlling crop diseases than race-specific resistance because of its broad spectrum and durability. Through a genome-wide association study, we report the identification of a natural allele of a C2H2-type transcription factor in rice that confers non-race-specific resistance to blast. A survey of 3,000 sequenced rice genomes reveals that this allele exists in 10% of rice, suggesting that this favorable trait has been selected through breeding. This allele causes a single nucleotide change in the promoter of the bsr-d1 gene, which results in reduced expression of the gene through the binding of the repressive MYB transcription factor and, consequently, an inhibition of H2O2 degradation and enhanced disease resistance. Our discovery highlights this novel allele as a strategy for breeding durable resistance in rice.

引用

页码：114 / +

页数：28

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