Assessment of exposure to influenza A viruses in pigs between weaning and market age

被引:1
作者
Ferreira, Juliana Bonin [1 ,2 ]
Poljak, Zvonimir [2 ]
Friendship, Robert [2 ]
Nagy, Eva [3 ]
Wideman, Greg [4 ]
Grgic, Helena [2 ]
机构
[1] North Carolina State Univ, Dept Populat Hlth & Pathobiol, Raleigh, NC 27695 USA
[2] Univ Guelph, Dept Populat Med, Guelph, ON, Canada
[3] Univ Guelph, Dept Pathobiol, Guelph, ON, Canada
[4] South West Vet Ontario Serv, Stratford, ON, Canada
关键词
Influenza A virus; Antibodies; Swine; Co-circulation; MATERNALLY-DERIVED ANTIBODIES; INFECTION DYNAMICS; IMMUNE-RESPONSE; SWINE; TRANSMISSION; FARMS; H1N1; CIRCULATION; ONTARIO;
D O I
10.1186/s13567-021-00927-9
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
Influenza A viruses (IAVs) are common causes of respiratory infection in pigs. The objective of this study was to characterize the circulation of IAVs between weaning and market age on the basis of development of antibody response and molecular epidemiology of detected viruses. Two batches of weaned pigs were followed in the nursery and finisher barns with a sample of 81 and 75 pigs. Nasal swabs and blood samples were collected from individual pigs for virological and serological analyses. A H3N2 subtype virus, of cluster IV, was detected in Study 1, with a maximum of 97.9% identity to HA gene of viruses previously isolated in Ontario. In Study 2, a H1N1 subtype virus, of 2009 H1N1 pandemic lineage, was detected, with a maximum of 97.8% identity to HA gene of viruses previously isolated in Ontario. On the basis of HA gene, it was observed that pigs were being detected with the same virus over time. The existence of antibody titers for IAV other than the isolated one confirmed that more than one subtype can circulate in the same population. In Study 1, pigs with higher numbers of IAV detection had lower serological titers for the same virus that was confirmed to circulate in the nursery (P < 0.01). Thorough knowledge of all endemic viral strains is fundamental for development of infection and disease control, particularly in complex production systems. This may include consideration of sampling and testing strategies which could detect circulation of all IAV variants, even if they have low prevalence.
引用
收藏
页数:14
相关论文
共 24 条
  • [1] Infection Dynamics of Pandemic 2009 H1N1 Influenza Virus in a Two-Site Swine Herd
    Allerson, M. W.
    Davies, P. R.
    Gramer, M. R.
    Torremorell, M.
    [J]. TRANSBOUNDARY AND EMERGING DISEASES, 2014, 61 (06) : 490 - 499
  • [2] The impact of maternally derived immunity on influenza A virus transmission in neonatal pig populations
    Allerson, Matt
    Deen, John
    Detmer, Susan E.
    Gramer, Marie R.
    Joo, Han Soo
    Romagosa, Anna
    Torremorell, Montserrat
    [J]. VACCINE, 2013, 31 (03) : 500 - 505
  • [3] Population dynamics of cocirculating swine influenza A viruses in the United States from 2009 to 2012
    Anderson, Tavis K.
    Nelson, Martha I.
    Kitikoon, Pravina
    Swenson, Sabrina L.
    Korslund, John A.
    Vincent, Amy L.
    [J]. INFLUENZA AND OTHER RESPIRATORY VIRUSES, 2013, 7 : 42 - 51
  • [4] [Anonymous], 2009, VET EPIDEMIOLOGIC RE
  • [5] Maternally-derived antibodies do not prevent transmission of swine influenza A virus between pigs
    Cador, Charlie
    Herve, Severine
    Andraud, Mathieu
    Gorin, Stephane
    Paboeuf, Frederic
    Barbier, Nicolas
    Queguiner, Stephane
    Deblanc, Celine
    Simon, Gaelle
    Rose, Nicolas
    [J]. VETERINARY RESEARCH, 2016, 47
  • [6] Cochran GW, 1967, STAT METHODS, V6
  • [7] Maternally-derived antibodies do not inhibit swine influenza virus replication in piglets but decrease excreted virus infectivity and impair post-infectious immune responses
    Deblanc, Celine
    Herve, Severine
    Gorin, Stephane
    Cador, Charlie
    Andraud, Mathieu
    Queguiner, Stephane
    Barbier, Nicolas
    Paboeuf, Frederic
    Rose, Nicolas
    Simon, Gaelle
    [J]. VETERINARY MICROBIOLOGY, 2018, 216 : 142 - 152
  • [8] Association between Influenza A Virus Infection and Pigs Subpopulations in Endemically Infected Breeding Herds
    Diaz, Andres
    Perez, Andres
    Sreevatsan, Srinand
    Davies, Peter
    Culhane, Marie
    Torremorell, Montserrat
    [J]. PLOS ONE, 2015, 10 (06):
  • [9] Longitudinal study of influenza A virus circulation in a nursery swine barn
    Ferreira, Juliana B.
    Grgic, Helena
    Friendship, Robert
    Wideman, Greg
    Nagy, Eva
    Poljak, Zvonimir
    [J]. VETERINARY RESEARCH, 2017, 48
  • [10] Genetic Characterization of H1N1 and H1N2 Influenza A Viruses Circulating in Ontario Pigs in 2012
    Grgic, Helena
    Costa, Marcio
    Friendship, Robert M.
    Carman, Susy
    Nagy, Eva
    Poljak, Zvonimir
    [J]. PLOS ONE, 2015, 10 (06):