Associated Autoimmune Diseases in Systemic Sclerosis Define a Subset of Patients with Milder Disease: Results from 2 Large Cohorts of European Caucasian Patients

被引:64
作者
Avouac, Jerome [1 ]
Airo, Paolo [7 ]
Dieude, Philippe [2 ]
Caramaschi, Paola [8 ]
Tiev, Kiet [3 ]
Diot, Elisabeth [4 ]
Sibilia, Jean [5 ]
Cappelli, Susanna [9 ]
Granel, Brigitte [6 ]
Vacca, Alessandra [10 ]
Wipff, Julien
Meyer, Olivier [2 ]
Kahan, Andre
Matucci-Cerinic, Marco [9 ]
Allanore, Yannick
机构
[1] Paris Descartes Univ, Serv Rhumatol A, Hop Cochin, Rheumatol Dept A, F-75014 Paris, France
[2] Univ Paris 07, Hop Bichat Claude Bernard, Dept Rheumatol, Paris, France
[3] Hop St Antoine, Dept Internal Med, APHP, F-75571 Paris, France
[4] CHU Bretonneau, INSERM, EMI U 00 10, F-37044 Tours, France
[5] Univ Strasbourg, Hautepierre Hosp, Dept Rheumatol, Strasbourg, France
[6] North Hosp 19915, Dept Internal Med, Marseille, France
[7] Spedali Civil Brescia, I-25125 Brescia, Italy
[8] Univ Verona, Dept Clin & Expt Med, Rheumatol Unit, I-37100 Verona, Italy
[9] Univ Florence, Dept Biomed, Rheumatol Sect, Florence, Italy
[10] Univ Cagliari, Dept Rheumatol, Cagliari, Italy
关键词
SYSTEMIC SCLEROSIS; AUTOIMMUNITY; THYROIDITIS; SJOGREN'S SYNDROME; PRIMARY BILIARY CIRRHOSIS; SJOGRENS-SYNDROME; T-CELLS; AUTOANTIBODIES; SCLERODERMA; CLASSIFICATION; DERMATOMYOSITIS; SUSCEPTIBILITY; PATHOGENESIS; POLYMYOSITIS; CRITERIA;
D O I
10.3899/jrheum.090815
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objective. To assess the prevalence and potential associations with the systemic sclerosis (SSc) phenotype of additional autoimmune diseases (AID). Methods. A multicenter study was performed in France and Italy to recruit consecutive European Caucasian patients with SSc systematically assessed for the coexistence of predefined AID known to occur with connective tissue diseases. Results. We recruited 585 French and 547 Italian patients with SSc. Specific AID were found in 114/585 (19%) French and 179/547 (33%) Italians with SSc (p < 0.0001). Sjogren's syndrome and thyroiditis were the predominant AID in both cohorts (12% for Sjogren's syndrome and 6% for thyroiditis in the combined populations). The frequency of myositis, primary biliary cirrhosis, rheumatoid arthritis, and systemic lupus erythematosus was low (< 4%) and similar in both cohorts. The coexistence of at least 1 of the AID in the whole cohort was associated in multivariate analysis with the limited cutaneous subtype, the presence of antinuclear antibodies, and a lower prevalence of digital ulcers. Conclusion. Our study shows that 21% of this large series of European Caucasian patients with SSc have developed at least 1 AID. This latter condition identified a subset of patients with milder disease. Thus, associations of AID and autoimmune background in SSc have to be considered for further therapeutic and biological investigations in SSc. (First Release Feb 1 2010; J Rheumatol 2010;37:608-14 doi:10.3899/jrheum.090815)
引用
收藏
页码:608 / 614
页数:7
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